지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 305 - 310 (6page)
이용수
초록· 키워드
오류제보하기
Microglia are emerging as critical regulators of innate immune responses in AD and other neurodegenerative disorders, highlighting the importance of understanding their molecular and cellular mechanisms. We attempted to determine the role of crosstalk signaling between IFN-γ and TGF-β in Aβ clearance by microglia cells. We used in vitro and in vivo mouse models that recapitulated acute and chronic aspects of microglial responses to Aβ peptides. We showed that crosstalk signaling between TGF-β and Smad2 was an important mediator of neuro-inflammation. These findings suggest that microglial TGF-β activity enhances the pathological progression to AD. As TGF-β displays broad regulatory effects on beneficial microglial functions, the activation of inflammatory crosstalk signaling between TGF-β and Smad2 may be a promising strategy to restore microglial functions, halt the progression of Aβ-driven pathology, and prevent AD development.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Recent Advances in the Development of TGF-β Signaling Inhibitors for Anticancer Therapy
대한암예방학회지
2020 .01
-
Role of the transforming growth factor (TGF)-β1 and TGF-β1 signaling pathway on the pathophysiology of respiratory pneumococcal infections
영남의대학술지
2017 .01
-
The Role of Tripartite Motif Family Proteins in TGF-β Signaling Pathway and Cancer
대한암예방학회지
2018 .01
-
Copper oxide nanoparticles induce a fibrotic response via TGF-β1/Smad3 signaling in human airway epithelial cells
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Copper oxide nanoparticles induce a fibrotic response via TGF-β1/Smad3 signaling in human airway epithelial cells
한국실험동물학회 학술발표대회 논문집
2017 .08
-
A study on the mechanism of resistance to non-small cell lung cancer therapeutic application using mouse orthotopic model
한국실험동물학회 학술발표대회 논문집
2021 .07
-
The Association of Blood-Based Inflammatory Factors IL-1β, TGF-β and CRP with Cognitive Function in Alzheimer’s Disease and Mild Cognitive Impairment
PSYCHIATRY INVESTIGATION
2021 .01
-
Role of the transforming growth factor (TGF)-β1 and TGF-β1 signaling pathway on the pathophysiology of respiratory pneumococcal infections
Journal of Yeungnam Medical Science
2017 .01
-
Effect of PHMG-p on TGF-β mediated signaling pathways in vivo and in vitro
환경독성보건학회 심포지엄 및 학술대회
2019 .04
-
Effect of PHMG-P on TGF-β mediated signaling pathways in animal models
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
Melatonin suppresses fibrotic responses induced by cigarette smoke via TGF-β1/Smad signaling
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Role of microglial inflammasome signaling in the neurodegenerative diseases
한국실험동물학회 학술발표대회 논문집
2020 .02
-
TGF-β Suppresses COX-2 Expression by Tristetraprolin-Mediated RNA Destabilization in A549 Human Lung Cancer Cells
Cancer Research and Treatment
2015 .01
-
The TGF-b1 Signaling Pathway According to Lauren"s Classification in Gastric Cancer
대한임상종양학회 학술대회지
2015 .02
-
Acute Effects of Transforming Growth Factor-1 on Neuronal Excitability and Involvement in the Pain of Rats with Chronic Pancreatitis
Journal of Neurogastroenterology and Motility (JNM)
2016 .01
-
Aloe vera prevents lung fibrosis by suppressing TGF-β/Smad pathway
한국실험동물학회 학술발표대회 논문집
2022 .07
-
4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
KLF10 as a tumor suppressor gene and its TGF-B signaling
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Combined Treatment With TGF-β1, Retinoic Acid, and Lactoferrin Robustly Generate Inducible Tregs (iTregs) Against High Affinity Ligand
Immune Network
2023 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-510-000302878