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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.23 No.4
- 발행연도
- 2018.12
- 수록면
- 301 - 308 (8page)
- DOI
- 10.3746/pnf.2018.23.4.301
이용수
초록· 키워드
오류제보하기
Citrus pomace (CP) is a by-product occurred during juice or other products processing. The enormous amount of CP caused serious environmental issues. However, CP is rich in a variety of bioactive compounds. In the present study, a water extract of CP (CPW) was prepared from the by-product and the in vitro and in vivo antioxidant activities of CPW were investigated. The in vitro antioxidant activities of CPW were evaluated by measuring the free radical scavenging activity and protective effects against 2,2-azobis(2-amidinopropane) hydrochloride (AAPH)-induced oxidative stress in Vero cells. CPW scavenges 1,1-diphenyl-2-picrylhydrazyl, alkyl, and hydroxyl radicals at IC50 of 0.16±0.00, 0.31±0.01, and 0.86 ±0.02 mg/mL, respectively. In addition, CPW improved cell viability and scavenged intracellular reactive oxygen species (ROS) in AAPH-stimulated Vero cells in a dose-dependent manner. The in vivo antioxidant activities of CPW were investigated in a model of AAPH-induced zebrafish embryos. CPW significantly improved the survival rates and reduced heartbeat rates in AAPH-stimulated zebrafish. Furthermore, the intracellular ROS and cell death levels were remarkably decreased in CPW-treated zebrafish. Therefore, the present results indicated that CPW possesses potent in vitro and in vivo antioxidant properties and could be a potential ingredient used in food, pharmaceutical, and cosmetic industries.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (41)
참고문헌 신청
[학술지(정기간행물)] - Valko M / 2007 / Free radicals and antioxidants in normal physiological functions and human disease / Int J Biochem Cell Biol 39 : 44 ~ 84
[학술지(정기간행물)] - I.P. Shanura Fernando / 2017 / FTIR characterization and antioxidant activity of water soluble crude polysaccharides of Sri Lankan marine algae / ALGAE 32 (1) : 75 ~ 86
[학술지(정기간행물)] - 이지혁 / 2015 / Evaluation of phlorofucofuroeckol-A isolated from Ecklonia cava (Phaeophyta) on anti-lipid peroxidation in vitro and in vivo / ALGAE 30 (4) : 313 ~ 323
[학술지(정기간행물)] - Kang MC / 2015 / Antioxidant activity of polysaccharide purified from Acanthopanax koreanum Nakai stems in vitro and in vivo zebrafish model / Carbohydr Polym 127 : 38 ~ 46
[학술지(정기간행물)] - Lei Wang / 2017 / Protective effect of gallic acid derivatives from the freshwater green alga Spirogyra sp. against ultraviolet B-induced apoptosis through reactive oxygen species clearance in human keratinocytes and zebrafish / ALGAE 32 (4) : 379 ~ 388
[학술지(정기간행물)] - I.P. Shanura Fernando / 2017 / FTIR characterization and antioxidant activity of water soluble crude polysaccharides of Sri Lankan marine algae / ALGAE 32 (1) : 75 ~ 86
[학술지(정기간행물)] - 이지혁 / 2015 / Evaluation of phlorofucofuroeckol-A isolated from Ecklonia cava (Phaeophyta) on anti-lipid peroxidation in vitro and in vivo / ALGAE 30 (4) : 313 ~ 323
[학술지(정기간행물)] - Kang MC / 2015 / Antioxidant activity of polysaccharide purified from Acanthopanax koreanum Nakai stems in vitro and in vivo zebrafish model / Carbohydr Polym 127 : 38 ~ 46
[학술지(정기간행물)] - Lei Wang / 2017 / Protective effect of gallic acid derivatives from the freshwater green alga Spirogyra sp. against ultraviolet B-induced apoptosis through reactive oxygen species clearance in human keratinocytes and zebrafish / ALGAE 32 (4) : 379 ~ 388
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UCI(KEPA) : I410-ECN-0101-2019-594-000300598