지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
TBC1D1 gene has known functional effects on body energy homeostasis and glucose uptake pathway in skeletal muscle tissue. This biological function is reported to have significant effects on traits of growth and meat quality in chicken. In this study, we focused on two single nucleotide polymorphisms (SNPs) (g.70179137A>G and g.70175861T>C) identified through SNP annotation information of Korean native chicken and previous literature for TBC1D1 in chicken. Association of SNPs in TBC1D1 with growth and serum clinical-chemical traits were evaluated. A total of 584 male and female birds from five Korean native chicken lines were used in the study. The SNP1 (g.70179137A>G) is located in intron 11 and SNP2 (g.70175861T>C) is a non-synonymous missense mutation in exon 10, responsible for the amino acid change from Methionine to Valine. The A allele of SNP1 and T allele of SNP2 had the highest allele frequencies. Both SNPs indicated moderate polymorphism information content values (0.25<PIC<0.5). Association results shown that SNP1 was significantly associated with BW00, BW20, GR14-16 and carcass weight (P<0.05). The AA genotype had higher value for all these traits except BW00. Whereas, genotype GG have lower values for BW20, GR14-16, GR18-20 and carcass weight. The sGOT level was significant with SNP1 but not with the SNP2. The GG genotype had the highest sGOT value and AG reported the lowest. BW20 was significantly associated with SNP2 (P<0.05). The body weight and carcass weight values of CC and TC genotypes were higher than those of TT genotype.
목차
ABSTRACT
INTRODUCTION
MATERIAL AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
[학술지(정기간행물)] - Ambo M / 2009 / Quantitative trait loci for performance traits in a broiler × layer cross / Anim Genet 40 (2) : 200 ~ 208
[학술지(정기간행물)] - Cahyadi M / 2014 / Quantitative trait loci and candidate genes for the economic traits in meat-type chicken / Worlds Poult Sci J 70 (2) : 329 ~ 342
[학술지(정기간행물)] - Muhammad Cahyadi / 2016 / Variance Component Quantitative Trait Locus Analysis for Body Weight Traits in Purebred Korean Native Chicken / ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 29 (1) : 43 ~ 50
[기타자료] - Dekkers JCM / 2007 / Marker-assisted selection in livestock - Case studies, Marker-assisted selection, Current Status and Future Perspectives in Crops, Livestock, Forestry and Fish / FAO
[학술지(정기간행물)] - Dokas J / 2016 / Tbc1d1deletion suppresses obesity in leptin-deficient mice / Int J Obes 40 (8) : 1242 ~ 1249
[학술지(정기간행물)] - Cahyadi M / 2014 / Quantitative trait loci and candidate genes for the economic traits in meat-type chicken / Worlds Poult Sci J 70 (2) : 329 ~ 342
[학술지(정기간행물)] - Muhammad Cahyadi / 2016 / Variance Component Quantitative Trait Locus Analysis for Body Weight Traits in Purebred Korean Native Chicken / ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 29 (1) : 43 ~ 50
[기타자료] - Dekkers JCM / 2007 / Marker-assisted selection in livestock - Case studies, Marker-assisted selection, Current Status and Future Perspectives in Crops, Livestock, Forestry and Fish / FAO
[학술지(정기간행물)] - Dokas J / 2016 / Tbc1d1deletion suppresses obesity in leptin-deficient mice / Int J Obes 40 (8) : 1242 ~ 1249
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UCI(KEPA) : I410-ECN-0101-2019-527-000299920