지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.96 No.2
- 발행연도
- 2019.2
- 수록면
- 78 - 85 (8page)
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초록· 키워드
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Purpose: Insistence that total regression of primary tumor would not represent long-term oncologic outcomes has been raised. Therefore, this study aimed to evaluate the outcomes of these patients after preoperative chemoradiotherapy (PCRT) and radical surgery and to evaluate the associated risk factors.
Methods: We included 189 patients with rectal cancer who showed total regression of the primary tumor after PCRT, followed by radical resection, between 2001 and 2012. Recurrence-free survival (RFS) was calculated using the Kaplan- Meier method, and the results were compared with 77 patients with Tis rectal cancer who received only radical resection. Factors associated with RFS were evaluated using Cox regression analysis.
Results: Sphincter-saving resection was performed for 146 patients (77.2%). Adjuvant chemotherapy was administered to 168 patients (88.9%). During the follow-up period, recurrence occurred in 17 patients (9%). The 5-year RFS was 91.3%, which was significantly lower than that of patients with Tis rectal cancer without PCRT (P = 0.005). In univariate analysis, preoperative CEA and histologic differentiation were associated with RFS. However, no factors were found to be associated with RFS.
Conclusion: RFS was lower in patients with total regression of primary rectal cancer after PCRT than in those with Tis rectal cancer without PCRT, and it would not be considered as the same entity with early rectal cancer or “disappeared tumor” status.
Methods: We included 189 patients with rectal cancer who showed total regression of the primary tumor after PCRT, followed by radical resection, between 2001 and 2012. Recurrence-free survival (RFS) was calculated using the Kaplan- Meier method, and the results were compared with 77 patients with Tis rectal cancer who received only radical resection. Factors associated with RFS were evaluated using Cox regression analysis.
Results: Sphincter-saving resection was performed for 146 patients (77.2%). Adjuvant chemotherapy was administered to 168 patients (88.9%). During the follow-up period, recurrence occurred in 17 patients (9%). The 5-year RFS was 91.3%, which was significantly lower than that of patients with Tis rectal cancer without PCRT (P = 0.005). In univariate analysis, preoperative CEA and histologic differentiation were associated with RFS. However, no factors were found to be associated with RFS.
Conclusion: RFS was lower in patients with total regression of primary rectal cancer after PCRT than in those with Tis rectal cancer without PCRT, and it would not be considered as the same entity with early rectal cancer or “disappeared tumor” status.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (25)
참고문헌 신청
Sauer R / 2004 / Preoperative versus postoperative chemoradiotherapy for rectal cancer / N Engl J Med 351:1731~1740
Sauer R / 2012 / Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer : results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years / J Clin Oncol 30:1926~1933
Habr-Gama A / 2004 / Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy : longterm results / Ann Surg 240:711~717
Garcia-Aguilar J / 2015 / Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision(ACOSOG Z6041) : results of an open-label, singlearm, multi-institutional, phase 2 trial / Lancet Oncol 16:1537~1546
Perez RO / 2013 / Transanal endoscopic microsurgery for residual rectal cancer(ypT0-2)following neoadjuvant chemoradiation therapy : another word of caution / Dis Colon Rectum 56:6~13
Sauer R / 2012 / Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer : results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years / J Clin Oncol 30:1926~1933
Habr-Gama A / 2004 / Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy : longterm results / Ann Surg 240:711~717
Garcia-Aguilar J / 2015 / Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision(ACOSOG Z6041) : results of an open-label, singlearm, multi-institutional, phase 2 trial / Lancet Oncol 16:1537~1546
Perez RO / 2013 / Transanal endoscopic microsurgery for residual rectal cancer(ypT0-2)following neoadjuvant chemoradiation therapy : another word of caution / Dis Colon Rectum 56:6~13
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UCI(KEPA) : I410-ECN-0101-2019-514-000442142