지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 58 - 67 (10page)
이용수
초록· 키워드
오류제보하기
Background: Diabetic neuropathy is one of the most devastating ailments of the peripheral nervous system. Neuropathic pain develops inw30% of diabetics. Here, we examined the suppressive effect of GSKG9 on neuropathic pain induced by streptozotocin (STZ).
Methods: Hyperglycemia was induced by intraperitoneal injection of STZ. Rats showing blood glucose level > 250 mg/dL were divided into five groups, and treatment groups received oral saline containing GS-KG9 (50 mg/kg, 150 mg/kg, or 300 mg/kg) twice daily for 4 wk. The effects of GS-KG9 on pain behavior, microglia activation in the lumbar spinal cord and ventral posterolateral (VPL) nucleus of the thalamus, and c-Fos expression in the dorsal horn of the lumbar spinal cord were examined.
Results: The development of neuropathic pain began at Day 5 and peaked at Week 4 after STZ injection. Mechanical and thermal pains were both significantly attenuated in GS-KG9-treated groups from 10d after STZ injection as compared to those in the STZ control. GS-KG9 also repressed microglia activation in L4 dorsal horn and VPL region of the thalamus. In addition, increase in c-Fos-positive cells within L4 dorsal horn lamina I and II of the STZ control group was markedly alleviated by GS-KG9.
Conclusion: These results suggest that GS-KG9 effectively relieves STZ-induced neuropathic pain by inhibiting microglial activation in the spinal cord dorsal horn and VPL region of the thalamus.
Methods: Hyperglycemia was induced by intraperitoneal injection of STZ. Rats showing blood glucose level > 250 mg/dL were divided into five groups, and treatment groups received oral saline containing GS-KG9 (50 mg/kg, 150 mg/kg, or 300 mg/kg) twice daily for 4 wk. The effects of GS-KG9 on pain behavior, microglia activation in the lumbar spinal cord and ventral posterolateral (VPL) nucleus of the thalamus, and c-Fos expression in the dorsal horn of the lumbar spinal cord were examined.
Results: The development of neuropathic pain began at Day 5 and peaked at Week 4 after STZ injection. Mechanical and thermal pains were both significantly attenuated in GS-KG9-treated groups from 10d after STZ injection as compared to those in the STZ control. GS-KG9 also repressed microglia activation in L4 dorsal horn and VPL region of the thalamus. In addition, increase in c-Fos-positive cells within L4 dorsal horn lamina I and II of the STZ control group was markedly alleviated by GS-KG9.
Conclusion: These results suggest that GS-KG9 effectively relieves STZ-induced neuropathic pain by inhibiting microglial activation in the spinal cord dorsal horn and VPL region of the thalamus.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (47)
참고문헌 신청
Leinonen A / 2004 / Diurnal blood glucose profiles in women with gestational diabetes with or without hypertension / Diabet Med 21:1181~1184
Martins JO / 2010 / Early phase of allergic airway inflammation in diabetic rats : role of insulin on the signaling pathways and mediators / Cell Physiol Biochem 26:739~748
Xu JT / 2006 / The role of tumor necrosis factor-alpha in the neuropathic pain induced by lumbar 5 ventral root transection in rat / Pain 123:306~321
Sommer C / 2004 / Recent findings on how proinflammatory cytokines cause pain : peripheral mechanisms in inflammatory and neuropathic hyperalgesia / Neurosci Lett 361:184~187
Park JS / 2009 / Anti-inflammatory mechanism of ginseng saponins in activated microglia / J Neuroimmunol 209:40~49
Martins JO / 2010 / Early phase of allergic airway inflammation in diabetic rats : role of insulin on the signaling pathways and mediators / Cell Physiol Biochem 26:739~748
Xu JT / 2006 / The role of tumor necrosis factor-alpha in the neuropathic pain induced by lumbar 5 ventral root transection in rat / Pain 123:306~321
Sommer C / 2004 / Recent findings on how proinflammatory cytokines cause pain : peripheral mechanisms in inflammatory and neuropathic hyperalgesia / Neurosci Lett 361:184~187
Park JS / 2009 / Anti-inflammatory mechanism of ginseng saponins in activated microglia / J Neuroimmunol 209:40~49
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UCI(KEPA) : I410-ECN-0101-2019-524-000425272