지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.2
- 수록면
- 28 - 35 (8page)
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초록· 키워드
오류제보하기
Objectives：The aim of this study was to investigate the association of plasma levels of inflammatory cytokines with dementia and mild cognitive impairment.
Methods：We compared serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-6(IL-6), and insulinlike growth factor-1(IGF-I) in patients with dementia(n=8), mild cognitive impairment(MCI, n=15) and normal elderly (n=14). The diagnosis of dementia was made by the Diagnostic Statistical Manual of Mental Disorders-4th edition (DSM-IV). MCI was diagnosed based on the criteria of the National Institute of Aging and Alzheimer Association(NIAAA) working group.
Results：When compared with normal controls, the levels of TNF-alpha and IL-6 were increased and level of IGF-I was decreased in MCI and dementia. Higher levels of TNF-alpha and IL-6 and lower level of IGF-I were also associated with increased age. However, when adjusted for age, the association between diagnosis and TNF-alpha, Il-6 and IGF-I was not significant.
Conclusion：The difference in plasma levels of inflammatory cytokines in dementia and MCI may be associated with aging.
Methods：We compared serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-6(IL-6), and insulinlike growth factor-1(IGF-I) in patients with dementia(n=8), mild cognitive impairment(MCI, n=15) and normal elderly (n=14). The diagnosis of dementia was made by the Diagnostic Statistical Manual of Mental Disorders-4th edition (DSM-IV). MCI was diagnosed based on the criteria of the National Institute of Aging and Alzheimer Association(NIAAA) working group.
Results：When compared with normal controls, the levels of TNF-alpha and IL-6 were increased and level of IGF-I was decreased in MCI and dementia. Higher levels of TNF-alpha and IL-6 and lower level of IGF-I were also associated with increased age. However, when adjusted for age, the association between diagnosis and TNF-alpha, Il-6 and IGF-I was not significant.
Conclusion：The difference in plasma levels of inflammatory cytokines in dementia and MCI may be associated with aging.
목차
서론
대상 및 방법
결과
고찰
참고문헌
참고문헌 (26)
참고문헌 신청
Gubandru M / 2013 / Alzheimer’s disease treated patients showed different patterns for oxidative stress and inflammation markers / Food Chem Toxicol 61:209~214
Pan W / 1997 / Tumor necrosis factor-α : a neuromodulator in the CNS / Neurosci Biobehav Rev 21:603~613
Helmy AA / 2012 / Role of interleukin 6 and alpha-globulins in differentiating Alzheimer and vascular dementias / Neurodegener Dis 9:81~86
Doré S / 1997 / Rediscovering an old friend, IGF-I: potential use in the treatment of neurodegenerative diseases / Trends Neurosci 20:326~331
Venters HD / 1999 / A new mechanism of neurodegeneration : a proinflammatory cytokine inhibits receptor signaling by a survival peptide / Proc Natl Acad Sci U S A 96:9879~9884
Pan W / 1997 / Tumor necrosis factor-α : a neuromodulator in the CNS / Neurosci Biobehav Rev 21:603~613
Helmy AA / 2012 / Role of interleukin 6 and alpha-globulins in differentiating Alzheimer and vascular dementias / Neurodegener Dis 9:81~86
Doré S / 1997 / Rediscovering an old friend, IGF-I: potential use in the treatment of neurodegenerative diseases / Trends Neurosci 20:326~331
Venters HD / 1999 / A new mechanism of neurodegeneration : a proinflammatory cytokine inhibits receptor signaling by a survival peptide / Proc Natl Acad Sci U S A 96:9879~9884
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UCI(KEPA) : I410-ECN-0101-2019-512-000433525