지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.24 No.1
- 발행연도
- 2019.3
- 수록면
- 64 - 69 (6page)
- DOI
- 10.3746/pnf.2019.24.1.64
이용수
초록· 키워드
오류제보하기
In addition to intestinal balance, probiotics are known to have beneficial effects on skin inflammation, metabolic diseases, and emotions. Previously, we have reported the skin anti-aging effects of Lactobacillus plantarum HY7714 (HY7714) in a clinical trial. To prove the protective skin effects of HY7714 through the intestinal tight junction (TJ), we investigated the effects of HY7714 on the intestines through tumor necrosis factor (TNF)-α induced TJ defects in Caco-2 cells. Specifically, 24 h treatment with HY7714 restored the decreased expression of zonula occludens-1, occludin, and claudin-1 compared to the TNF-α-treated groups (P<0.05). It also attenuated the level of pro-inflammatory cytokines interleukin- 6, 8, and 1β. Further, increases in the mRNA levels of Elk-1, nuclear factor-κB, and myosin light chain kinase expression induced by TNF-α were recovered by HY7714. These findings imply that HY7714 improves intestinal barrier integrity and is a potential therapeutic agent for dysfunctions derived from TJ defects.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (43)
참고문헌 신청
Marietta E / 2015 / Immunogenetic control of the intestinal microbiota / Immunology 145:313~322
Chiu YH / 2014 / Probiotic actions on diseases : implications for therapeutic treatments / Food Funct 5:625~634
Foster JA / 2013 / Gut-brain axis : how the microbiome influences anxiety and depression / Trends Neurosci 36:305~312
Guéniche A / 2009 / Probiotics for photoprotection / Dermatoendocrinol 1:275~279
Satoh T / 2015 / Effect of Bifidobacterium breve B-3 on skin photoaging induced by chronic UV irradiation in mice / Benef Microbes 6:497~504
Chiu YH / 2014 / Probiotic actions on diseases : implications for therapeutic treatments / Food Funct 5:625~634
Foster JA / 2013 / Gut-brain axis : how the microbiome influences anxiety and depression / Trends Neurosci 36:305~312
Guéniche A / 2009 / Probiotics for photoprotection / Dermatoendocrinol 1:275~279
Satoh T / 2015 / Effect of Bifidobacterium breve B-3 on skin photoaging induced by chronic UV irradiation in mice / Benef Microbes 6:497~504
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UCI(KEPA) : I410-ECN-0101-2019-594-000543251