지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.8
- 수록면
- 281 - 290 (10page)
- DOI
- 10.7783/KJMCS.2018.26.4.281
이용수
초록· 키워드
오류제보하기
Background: Lung cancer, the most common malignant disease worldwide, is the predominant cause of cancer deaths, particularly amongst men. Therefore, various researchers have focused on the growth inhibitory effects of medicinal plants used in traditional Korean medicine. This study aimed to investigate the growth inhibitory effects of ethanol extracts of Rubiae radix, Inulae flos, Nelumbinis receptaculum, Astilbe radix, and Lagerstroemia flos on NCI-H1229 cells.
Method and Results: The viability of NCI-H1229 cells was evaluated in vitro using an MTS assay. Treatment with the ethanol extracts of the selected medicinal plants at 500 ㎍/㎖ reduced NCI-H1229 cell viability and increased apoptotic cell death and caspase-3 activation. In addition, treatment with ethanol extracts of Inulae flos and Astilbe radix increases DNA fragmentation, as measured by the TUNEL assay.
Conclusions: These results indicated that ethanol extracts of Rubiae radix, Inulae flos, Nelumbinis receptaculum, Astilbe radix, and Lagerstroemia flos exhibited growth inhibitory effects, inducing apoptotic cell death, DNA fragmentation and caspase-3 activation in NCI-H1229 cells. Therefore, these medicinal plant extracts may be used in the development of natural medicines to inhibit the growth of lung cancers. However, further study is needed to determine the active ingredients of the ethanol extracts from medicinal plants that are reposible for the inhibitory effect on lung cancer cell grwoth.
Method and Results: The viability of NCI-H1229 cells was evaluated in vitro using an MTS assay. Treatment with the ethanol extracts of the selected medicinal plants at 500 ㎍/㎖ reduced NCI-H1229 cell viability and increased apoptotic cell death and caspase-3 activation. In addition, treatment with ethanol extracts of Inulae flos and Astilbe radix increases DNA fragmentation, as measured by the TUNEL assay.
Conclusions: These results indicated that ethanol extracts of Rubiae radix, Inulae flos, Nelumbinis receptaculum, Astilbe radix, and Lagerstroemia flos exhibited growth inhibitory effects, inducing apoptotic cell death, DNA fragmentation and caspase-3 activation in NCI-H1229 cells. Therefore, these medicinal plant extracts may be used in the development of natural medicines to inhibit the growth of lung cancers. However, further study is needed to determine the active ingredients of the ethanol extracts from medicinal plants that are reposible for the inhibitory effect on lung cancer cell grwoth.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCE
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
노루오줌 에탄올 추출물의 산화스트레스 및 대장암 세포 억제활성
한국약용작물학회지
2018 .04
-
도라지 잎 에탄올 추출물의 주요 성분 분석 및 마우스 대식세포와 인체 폐암세포에서 항염효과
한국식품영양학회지
2024 .04
-
Evaluation of Pharmacological Activities of Ethanol Extracts Prepared from Selected Korean Medicinal Plants
한국식품위생안전성학회지
2018 .01
-
Screening of the Antioxidant Activity from Medicinal Plant Extracts
한국식품영양과학회 학술대회발표집
2016 .10
-
Antioxidant and Anti-Neurotoxic Effects of Ethanol Extracts from Medicinal Plants Mainly Cultivated in Korea
한국식품영양과학회 학술대회발표집
2022 .10
-
Growth Inhibitory Effect of Turmeric Ethanolic Extract on Lung Cancer Cells
한국약용작물학회 학술대회논문집
2017 .09
-
선복화 에탄올 추출물의 Nitric Oxide 생성, 산화스트레스 및 대장암 세포 억제효과
한국약용작물학회지
2018 .02
-
Antioxidative Activities in Domestic and Foreign Glycyrrhizae Radix Ethanol Extract
한국식품영양과학회 학술대회발표집
2015 .08
-
Genotoxicity Evaluation of an Ethanol Extract Mixture of Astragali Radix and Salviae miltiorrhizae Radix
한국식품영양과학회 학술대회발표집
2018 .10
-
Gochujang, a Korean traditional food has the growth inhibitory effects in gastric cancer cells
한국식품영양과학회 학술대회발표집
2023 .10
-
Anti-cancer effects and molecular mechanisms of Gossypin in human non-small cell lung cancer, A549 cell
한국식품영양과학회 학술대회발표집
2022 .10
-
새싹 밀의 추출용매에 따른 생리활성 평가
한국식품영양학회지
2019 .01
-
Physiological Activities of Reflux Ethanol Extracts from Lithospermi Radix
한국식품영양과학회 학술대회발표집
2016 .10
-
Antioxidant Effect of Platycodonis Radix Seed Ethanol Extract in HepG2 hepatoma cells
한국식품영양과학회 학술대회발표집
2016 .10
-
에탄올 농도별 당유자 잎의 최적추출조건 및 생리활성 평가
Journal of Plant Biotechnology
2019 .01
-
건왕대추 열수추출물의 폐암세포 증식 억제 효과
한국원예학회 학술발표요지
2023 .05
-
Growth Inhibitory Effects of Turmeric Extract and its Synergy with Black Pepper Extract on Human Lung Cancer Cells
한국약용작물학회 학술대회논문집
2018 .10
-
Antiviral and Antimicrobial Activity of Medicinal Plant Extracts
한국약용작물학회 학술대회논문집
2015 .05
-
Antioxidant and Antidiabetic Activity of Extracts from Medicinal Plants
한국식품영양과학회 학술대회발표집
2022 .10
-
Industrial Applications of Jeju Medicinal Plants
한국식품영양과학회 학술대회발표집
2016 .10
이 논문의 저자 정보
이 논문과 함께 이용한 논문
한약재인 석위(Pyrrosia lingua) 유래 추출물의 α-MSH로 자극된 B16F10 mouse melanoma cell에서 MITF 매개 멜라닌 합성 신호전달 경로의 억제조절에 의한 anti-melanogenic 효과
홍신협
,
이은호
,
박혜진
외 3명
한국식품영양과학회 학술대회발표집
2021
.10
한약재 품질관리를 위한 미생물학적 오염도 평가
이영섭
,
반아라
,
김선미
외 7명
한국약용작물학회 학술대회논문집
2015
.05
국산 한약재를 이용한 천연 화장품 소재 개발
정동진
,
김호진
,
김수현
외 3명
한국식품영양과학회 학술대회발표집
2018
.10
생체모방공학을 이용한 조직 재생 및 재생 의학의 동향
양희석
BT NEWS
2013
.06
양파, 사과, 오이, 생강, 브로콜리 혼합물들 및 이들에 함유된 생리활성 물질의 RBL-2H3 세포에서 알레르기 반응 저해효과
정미자
,
이상현
,
김덕순
Food Science and Preservation
2020
.12
최근 본 자료
댓글(0)
0