지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.8
- 수록면
- 317 - 327 (11page)
- DOI
- 10.7783/KJMCS.2018.26.4.317
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초록· 키워드
오류제보하기
Background: The root of Angelica gigas Nakai is used as a traditional herbal medicine in Korea for the treatment of many diseases. However, the poor water solubility of the active components in A. gigas Nakai is a major obstacle to its bioavailability.
Methods and Results: This work aimed at enhancing the solubility of the active compounds of A. gigas Nakai by a chemical (using a surfactant) and physical (hot melt extrusion, HME) crosslinking method. Fourier transform infrared spectroscopy revealed multiple peaks in the case of the extrudate solids, attributable to new functional groups including carboxylic acid, alkynes, and benzene derivatives. Differential scanning calorimetry analysis showed that the extrudate soilid had a lower glass transition temperature (T<SUB>g</SUB>) and enthalpy (ΔH) (T<SUB>g</SUB> : 43℃, ΔH : < 6 J/g) as compared to the non-extrudate (T<SUB>g</SUB> : 68.5℃, ΔH : 123.2) formulations. X-ray powder diffraction analysis revealed the amorphization of crystalline materials in the extrudate solid. In addition, enhanced solubility (53%), nanonization (403 ㎚), and a higher amount of extracted phenolic compounds were achieved in the extrudate solid than in the non-extrudate (solubility : 36%, nanonization : 1,499 ㎚) formulation. Among the different extrudates, acetic acid and span 80 mediated formulations showed superior extractions efficiency.
Conclusions: HME successfully enhanced the production of amorphous nano dispersions of phenolic compound including decursin from extrudate solid formulations.
Methods and Results: This work aimed at enhancing the solubility of the active compounds of A. gigas Nakai by a chemical (using a surfactant) and physical (hot melt extrusion, HME) crosslinking method. Fourier transform infrared spectroscopy revealed multiple peaks in the case of the extrudate solids, attributable to new functional groups including carboxylic acid, alkynes, and benzene derivatives. Differential scanning calorimetry analysis showed that the extrudate soilid had a lower glass transition temperature (T<SUB>g</SUB>) and enthalpy (ΔH) (T<SUB>g</SUB> : 43℃, ΔH : < 6 J/g) as compared to the non-extrudate (T<SUB>g</SUB> : 68.5℃, ΔH : 123.2) formulations. X-ray powder diffraction analysis revealed the amorphization of crystalline materials in the extrudate solid. In addition, enhanced solubility (53%), nanonization (403 ㎚), and a higher amount of extracted phenolic compounds were achieved in the extrudate solid than in the non-extrudate (solubility : 36%, nanonization : 1,499 ㎚) formulation. Among the different extrudates, acetic acid and span 80 mediated formulations showed superior extractions efficiency.
Conclusions: HME successfully enhanced the production of amorphous nano dispersions of phenolic compound including decursin from extrudate solid formulations.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (53)
참고문헌 신청
Agrawal S / 2004 / Solid-state characterization of rifampicin samples and its biopharmaceutic relevance / European Journal of Pharmaceutical Science 22:127~144
Ansel HC / 1985 / Introduction to pharmaceutical dosage forms / Lea and Febiger :147~149
배인영 / 2011 / Estrogenic Effects of Various Extracts from Chamdanggui (Angelica gigas Nakai) and Sogdan (Phlomis umbrosa Turcz) / Food Science and Biotechnology 20(4):1113~1118
Baird JA / 2012 / Evaluation of amorphous solid dispersion properties using thermal analysis techniques / Advance Drug Delivery Reviews 64:396~421
Braca A / 2003 / Antioxidant and free radical scavenging activity of flavonol glycosides from different Aconitum species / Journal of Ethnopharmacology 86:63~67
Ansel HC / 1985 / Introduction to pharmaceutical dosage forms / Lea and Febiger :147~149
배인영 / 2011 / Estrogenic Effects of Various Extracts from Chamdanggui (Angelica gigas Nakai) and Sogdan (Phlomis umbrosa Turcz) / Food Science and Biotechnology 20(4):1113~1118
Baird JA / 2012 / Evaluation of amorphous solid dispersion properties using thermal analysis techniques / Advance Drug Delivery Reviews 64:396~421
Braca A / 2003 / Antioxidant and free radical scavenging activity of flavonol glycosides from different Aconitum species / Journal of Ethnopharmacology 86:63~67
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