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논문 기본 정보

자료유형
학술저널
저자정보
Hee Jung Choi (Pusan National University) Bo Sun Joo (Pusan National University) Mi Ju Park (Pusan National University) Min Jung Park (Korea Institution for Public Sperm Bank) Boram Bae (Pusan National University) Bo Sung Kim (Pusan National University) Hye Rin Park (Pusan National University) Keuk Jun Kim (DaeKyeung University) Hee Jin Yang (CHO-A Pharm) Jeong Eun Yoo (Daejeon University) Tae Wook Chung (Pusan National University) Jongkil Joo (Pusan National University Hospital) Ki Tae Ha (Pusan National University)
저널정보
한의병리학회 동의생리병리학회지 동의생리병리학회지 제33권 제2호
발행연도
2019.4
수록면
141 - 150 (10page)
DOI
10.15188/kjopp.2019.04.33.2.141

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초록· 키워드

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Despite the development of assisted reproduction technologies (ART) including in vitro fertilization (IVF), the poor ovarian response and endometrial receptivity remains clinically a major unmet need. Although these problems are difficulties to solve in infertility treatment, there are no good therapeutic option yet. Traditional herbal remedies and acupuncture, therefore are being proposed as alternative treatment. Our group found that traditional herbal medicines such as Paeonia lactiflora L.(PL, 芍藥), Cyperus rotundus L.(CR, 香附子), and Perilla frutescens (PF, 紫蘇葉) could improve endometrial receptivity. In this study, we found out Yeosin-san (如神散) as an optimal herbal formula via combination of the previously established herbal medicines. Yeosin-san is a traditional Korean medical formula which was established by Ziming Jin (陳自明) and recorded in Furendaiquanliangfang (婦人大全良方) at first. The formula traditionally used for treating abnormal uterine bleeding and leukorrhea. It showed a highest effect on leukemia inhibitory factor (LIF) expression and on the adhesion between trophoblastic cells and endometrial cells. In addition, it has been shown that the Yeosin-san not only increases the endometrial receptivity to improve the embryo implantation but also enhances the ovary function by expressing the angiogenesis-related genes. Here we suggest that Yeosin-san could be a novel and effective candidate for treating female infertility.

목차

Introduction
Materials and Methods
Results
Discussion
Conclusion
References

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UCI(KEPA) : I410-ECN-0101-2019-519-000779814