지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.4
- 수록면
- 312 - 318 (7page)
이용수
초록· 키워드
오류제보하기
Background: To date, no study has described disease progression in Asian patients infected with HIV-1 subtype D.
Methods: To determine whether the disease progression differs in patients infected with subtypes D and B prior to starting combination antiretroviral therapy, the annual decline (AD) in CD4þ T cell counts over 96±59 months was retrospectively analyzed in 163 patients and compared in subtypes D and B based on the nef gene.
Results: CD4þ T cell AD was significantly higher in the six subtype Deinfected patients than in the 157 subtype Beinfected patients irrespective of Korean Red Ginseng (KRG) treatment (p < 0.001). Of these, two subtype Deinfected patients and 116 subtype Beinfected patients had taken KRG. AD was significantly lower in patient in the KRG-treated group than in those in the KRG-naïve group irrespective of subtype (p < 0.05). To control for the effect of KRG, patients not treated with KRG were analyzed, with AD found to be significantly greater in subtype Deinfected patients than in subtype Beinfected patients (p < 0.01). KRG treatment had a greater effect on AD in subtype Deinfected patients than in subtype B einfected patients (4.5-fold vs. 1.6-fold). Mortality rates were significantly higher in both the 45 KRGnaïve (p < 0.001) and all 163 (p < 0.01) patients infected with subtype D than subtype B.
Conclusion: Subtype D infection is associated with a >2-fold higher risk of death and a 2.9-fold greater rate of progression than subtype B, regardless of KRG treatment.
Methods: To determine whether the disease progression differs in patients infected with subtypes D and B prior to starting combination antiretroviral therapy, the annual decline (AD) in CD4þ T cell counts over 96±59 months was retrospectively analyzed in 163 patients and compared in subtypes D and B based on the nef gene.
Results: CD4þ T cell AD was significantly higher in the six subtype Deinfected patients than in the 157 subtype Beinfected patients irrespective of Korean Red Ginseng (KRG) treatment (p < 0.001). Of these, two subtype Deinfected patients and 116 subtype Beinfected patients had taken KRG. AD was significantly lower in patient in the KRG-treated group than in those in the KRG-naïve group irrespective of subtype (p < 0.05). To control for the effect of KRG, patients not treated with KRG were analyzed, with AD found to be significantly greater in subtype Deinfected patients than in subtype Beinfected patients (p < 0.01). KRG treatment had a greater effect on AD in subtype Deinfected patients than in subtype B einfected patients (4.5-fold vs. 1.6-fold). Mortality rates were significantly higher in both the 45 KRGnaïve (p < 0.001) and all 163 (p < 0.01) patients infected with subtype D than subtype B.
Conclusion: Subtype D infection is associated with a >2-fold higher risk of death and a 2.9-fold greater rate of progression than subtype B, regardless of KRG treatment.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (43)
참고문헌 신청
Kanki PJ / 1999 / Human immunodeficiency virus type 1subtypes differ in disease progression / J Infect Dis 179:68~73
Kaleebu P / 2002 / Effect of human immunodeficiency virus(HIV)type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda / J Infect Dis 185:1244~1250
Baeten JM / 2007 / HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads / J Infect Dis 195:1177~1180
Morgan D / 2001 / The stability between two HIV-1RNA measurements one year apart and the relationship with HIV subtype in rural Uganda / Int J STD AIDS 12:116~121
Alaeus A / 1999 / Similar rate of disease progression among individuals infected with HIV-1 genetic subtypes A-D / AIDS 13:901~907
Kaleebu P / 2002 / Effect of human immunodeficiency virus(HIV)type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda / J Infect Dis 185:1244~1250
Baeten JM / 2007 / HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads / J Infect Dis 195:1177~1180
Morgan D / 2001 / The stability between two HIV-1RNA measurements one year apart and the relationship with HIV subtype in rural Uganda / Int J STD AIDS 12:116~121
Alaeus A / 1999 / Similar rate of disease progression among individuals infected with HIV-1 genetic subtypes A-D / AIDS 13:901~907
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Impact of HIV-1 subtypes on gross deletion in the nef gene after Korean Red Ginseng treatment
Journal of Ginseng Research
2022 .11
-
Outcome Differences by Delirium Motor Subtype in Patients with Ischemic Stroke
PSYCHIATRY INVESTIGATION
2019 .01
-
Molecular subtypes and imaging phenotypes of breast cancer
ULTRASONOGRAPHY
2016 .01
-
Integrative multi-omics profiling of resectable pancreatic cancer reveals clinically relevant molecular subtypes with precision strategies beyond the clinical staging system
대한임상종양학회 학술대회지
2021 .06
-
Investigation of the Subtypes of Nonsuicidal Self-Injury Based on the Forms of Self-Harm Behavior: Examining Validity and Utility via Latent Class Analysis and Ecological Momentary Assessment
Journal of Korean Medical Science
2023 .05
-
Radiologic Subtypes and Treatment Outcome of Unclassifiable Type Mycobacterium avium Complex Pulmonary Disease
Journal of Korean Medical Science
2023 .01
-
Clinical Implication of Maumgyeol Basic Biotypes–Electroencephalography- and Photoplethysmogram-Based Bwave State Inventory
PSYCHIATRY INVESTIGATION
2024 .05
-
Clinicopathological feature and treatment outcome of patients with colorectal laterally spreading tumors treated by endoscopic submucosal dissection
Intestinal research
2019 .01
-
Distribution and Characteristics of Meibomian Gland Dysfunction Subtypes: A Multicenter Study in South Korea
Korean Journal of Ophthalmology
2019 .01
-
Breast Cancer Subtype as a Predictor of Lymph Node Metastasis according to the SEER Registry
Journal of Breast Cancer
2015 .01
-
Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma
Annals of Surgical Treatment and Research
2015 .12
-
Impacts of Subtype on Clinical Feature and Outcome of Male Breast Cancer: Multicenter Study in Korea (KCSG BR16-09)
Cancer Research and Treatment
2023 .01
-
Young Age Is Associated with Increased Locoregional Recurrence in Node-Positive Breast Cancer with Luminal Subtypes
Cancer Research and Treatment
2017 .01
-
Determination of Clinical Characteristics of Mycobacterium kansasii -Derived Species by Reanalysis of Isolates Formerly Reported as M. kansasii
Annals of Laboratory Medicine
2021 .09
-
Molecular Profiling of Breast Carcinoma in Almadinah, KSA: Immunophenotyping and Clinicopathological Correlation
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
범죄로 수감중인 국내 조현병 환자의 충동적 공격성과 계획적 공격성의 특성 비교
대한조현병학회지
2021 .01
-
Prognostic Influence of BCL2 on Molecular Subtypes of Breast Cancer
Journal of Breast Cancer
2017 .01
-
유방암의 Subtype에 따른 치료 방침
대한외과학회 학술대회 초록집
2019 .05
-
The Outcomes and Recurrence Patterns According to Breast Cancer Subtypes in Korean Women
대한임상종양학회 학술대회지
2015 .02
-
Nationwide Statistical Analysis of Lymphoid Malignancies in Korea
Cancer Research and Treatment
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0