지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.7
- 수록면
- 431 - 440 (10page)
- DOI
- 10.11002/kjfp.2019.26.4.431
이용수
초록· 키워드
오류제보하기
This study aimed to assess the inhibitory potential of Perilla frutescens methanolic extract (PE) and its fractions towards melanoma cells as an herbal medicine. PE (100-400 ㎍/mL) effectively decreased the viability of the mouse and human melanoma cells (B16 and SK-MEL-2, respectively), whereas, HaCaT human keratinocytes remained un-damaged. It also induced B16 cell apoptosis, as determined by flow cytometry, Hoechst 33258 staining, and DNA fragmentation. Amongst PE fractions, ethyl acetate fraction (PEEF) displayed the most significant anticancer activity in B16 cells. It also exhibited a significant proliferation inhibitory effect on B16 cells as compared to the butanol (PEBF) and water fractions (PEWF). Furthermore, PEEF induced apoptotic cell death, through increased nuclei condensation, DNA fragmentation, and sub-G1 cell cycle arrest. PEEF-induced apoptosis was observed to be involved with the up-regulation of pro-apoptotic caspase-3, -9, Bax, and cleaved PARP, and the down-regulation of anti-apoptotic Bcl-2 protein levels. The total phenolic contents of PEEF were 2.87 and 5.39 times higher than those of PEBF and PEWF. The findings demonstrated that phenolic compound-rich PEEF induced caspase-dependent apoptosis in melanoma cells, and that it could be used as an herbal medicine and functional food material.
목차
Abstract
Introduction
Materials and methods
Results
Discussion
References
참고문헌 (31)
참고문헌 신청
Negi VS / 2011 / Perilla frutescens in transition: a medicinal and oil yielding plant need instant conservation, a case study from Central Himalaya, India / Environ We Int J Sci Tech 6:193~200
Zhou XJ / 2014 / Structural characterisation and antioxidant activity evaluation of phenolic compounds from cold-pressed Perilla frutescens var. arguta seed flour / Food Chem 164:150~157
Asif M / 2012 / Phytochemical study of polyphenols in Perilla frutescens as an antioxidant / Avicenna J Phytomed 2:169~178
Ryu JH / 2002 / Two neolignans from Perilla frutescens and their inhibition of nitric oxide synthase and tumor necrosis factor-α expression in murine macrophage cell line RAW 264. 7 / Bioorg Med Chem Lett 12:649~651
Qiu J / 2011 / Subinhibitory concentrations of perilla oil affect the expression of secreted virulence factor genes in Staphylococcus aureus / PloS One 6:1~8
Zhou XJ / 2014 / Structural characterisation and antioxidant activity evaluation of phenolic compounds from cold-pressed Perilla frutescens var. arguta seed flour / Food Chem 164:150~157
Asif M / 2012 / Phytochemical study of polyphenols in Perilla frutescens as an antioxidant / Avicenna J Phytomed 2:169~178
Ryu JH / 2002 / Two neolignans from Perilla frutescens and their inhibition of nitric oxide synthase and tumor necrosis factor-α expression in murine macrophage cell line RAW 264. 7 / Bioorg Med Chem Lett 12:649~651
Qiu J / 2011 / Subinhibitory concentrations of perilla oil affect the expression of secreted virulence factor genes in Staphylococcus aureus / PloS One 6:1~8
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UCI(KEPA) : I410-ECN-0101-2019-059-000954185