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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
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- 1 - 7 (7page)
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Background: Apoptosis is a process of programmed cell death, and apoptosis defect results in serious diseases such as cancer. Apoptosis induction is one of the key mechanisms of anti-cancer agents. This study was aimed to find anti-prostate cancer compounds from marine-derived fungus Microsporum sp. Results: We found that physcion isolated from the fermentation broth extract of the marine fungus Microsporum sp. strain MFS-YL decreases the cell proliferation of PC3 human prostate cancer cells. Physcion induced cell apoptosis as determined by Annexin V/propidium iodide double staining. Physcion downregulated the anti-apopotoic proteins such as Ras, Bcl-xL, and Bcl-2, whereas upregulated the pro-apoptotic Bax. Physcion also activated caspase-3, caspase-8, and caspase-9. Conclusion: These results suggest that physcion from Microsporum sp. inhibits the proliferation of PC3 human prostate cancer cells via the pathway leading to apoptotic cell death. Physcion may be a potential candidate in the field of anticancer drug discovery against human prostate cancer.
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참고문헌 (27)
참고문헌 신청
Almeida AP / 2010 / The in vitro anticancer activity of the crude extract of the spongeassociated fungus Eurotium cristatum and its secondary metabolites / J Nat Pharma 1:25~29
Attaay DH / 1993 / Marine biotechnology pharmaceutical and bioactive natural products / Plenum Press :125~129
Blunt JW / 2014 / Marine natural products / Nat Prod Rep 31:160~258
Chen X / 2015 / Physcion induces mitochondria-driven apoptosis in colorectal cancer cells via downregulating EMMPRIN / Eur J Pharmacol 764:124~133
Elf S / 2017 / Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin / Oncogene 36:254~262
Attaay DH / 1993 / Marine biotechnology pharmaceutical and bioactive natural products / Plenum Press :125~129
Blunt JW / 2014 / Marine natural products / Nat Prod Rep 31:160~258
Chen X / 2015 / Physcion induces mitochondria-driven apoptosis in colorectal cancer cells via downregulating EMMPRIN / Eur J Pharmacol 764:124~133
Elf S / 2017 / Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin / Oncogene 36:254~262
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Apoptotic effect of physcion isolated from marine fungus, Microsporum sp. in PC3 human prostate cancer cells
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