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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 255 - 262 (8page)
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초록· 키워드
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Background/Aims: Information regarding the efficacy of early infliximab treatment in pediatric patients with Crohn’s disease (CD) is limited. We aimed to evaluate the impact of early combined immunosuppression on linear growth in pediatric patients with CD by performing step-up comparisons. Methods: This retrospective study included pediatric patients with moderate-to-severe CD, who received a combination therapy with infliximab and azathioprine for at least 3 years and sustained corticosteroid-free remission without loss of response. The z-scores of the growth indicators obtained at the time of diagnosis and annually for 3 years thereafter were compared between the two groups. Results: The early combined immunosuppression group displayed significantly increased linear growth 3 years after diagnosis (p=0.026). A significant difference was also observed in the linear growth 3 years after diagnosis between subgroups of Tanner stages 1–2 (p=0.016). Conclusions: The early introduction of biologics should be considered to improve linear growth in pediatric patients with CD.
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참고문헌 (32)
참고문헌 신청
Ruemmele FM / 2014 / Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease / J Crohns Colitis 8:1179~1207
Caprilli R / 2006 / European evidence based consensus on the diagnosis and management of Crohn's disease: special situations / Gut 55(Suppl 1):i36~i58
Hyams J / 2007 / Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children / Gastroenterology 132:863~873
Hyams JS / 2012 / Safety and efficacy of adalimumab for moderate to severe Crohn's disease in children / Gastroenterology 143:365~374
D'Haens G / 2008 / Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomized trial / Lancet 371:660~667
Caprilli R / 2006 / European evidence based consensus on the diagnosis and management of Crohn's disease: special situations / Gut 55(Suppl 1):i36~i58
Hyams J / 2007 / Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children / Gastroenterology 132:863~873
Hyams JS / 2012 / Safety and efficacy of adalimumab for moderate to severe Crohn's disease in children / Gastroenterology 143:365~374
D'Haens G / 2008 / Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomized trial / Lancet 371:660~667
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