지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 30 - 37 (8page)
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초록· 키워드
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Background/Aims: Eosinophilic esophagitis (EoE) is often erroneously diagnosed as gastroesophageal reflux disease (GERD). The aim of this study is to investigate the prevalence of EoE and the expression of tight junction (TJ) proteins in patients with GERD symptoms. Methods: One hundred patients with GERD symptoms and 10 healthy controls were prospectively studied. Sixty-two patients had symptoms refractory to proton pump inhibitors (PPI). All patients underwent esophageal biopsy. Patients were diagnosed with EoE if the number of eosinophil granulocytes per high-power field was ≥15. Immunohistochemical analysis of TJ proteins (claudin-1, claudin-4, occludin, and zonula occludin-1 [ZO-1]) was performed. Results: EoE was diagnosed in six of 100 patients (6%) with GERD symptoms and in six patients (9.7%) of 62 patients with PPI-refractory GERD. Only one had typical EoE endoscopic findings. The proportion of ZO-1-positive cells was significantly lower in the lower than in the middle esophagus (56.0%±14.0% vs 66.0%±11.5%, p<0.05). There were no significant correlations between TJ protein expression and GERD symptoms. Conclusions: The prevalence of EoE among patients with PPI-refractory GERD is approximately 10%. Regardless of endoscopic findings, esophageal biopsy is crucial in diagnosing EoE. The disruption of ZO-1 expression in the lower esophagus is significantly associated with GERD symptoms.
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참고문헌 (37)
참고문헌 신청
Kang JY / 2004 / Systematic review: geographical and ethnic differences in gastro-oesophageal reflux disease / Aliment Pharmacol Ther 20:705~717
Minatsuki C / 2013 / Background factors of reflux esophagitis and non-erosive reflux disease: a cross-sectional study of 10,837 subjects in Japan / PLoS One 8:e69891
Furuta GT / 2007 / Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment / Gastroenterology 133:1342~1363
Woodland P / 2013 / Assessment and protection of esophageal mucosal integrity in patients with heartburn without esophagitis / Am J Gastroenterol 108:535~543
Dunbar KB / 2016 / Association of acute gastroesophageal reflux disease with esophageal histologic changes / JAMA 315:2104~2112
Minatsuki C / 2013 / Background factors of reflux esophagitis and non-erosive reflux disease: a cross-sectional study of 10,837 subjects in Japan / PLoS One 8:e69891
Furuta GT / 2007 / Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment / Gastroenterology 133:1342~1363
Woodland P / 2013 / Assessment and protection of esophageal mucosal integrity in patients with heartburn without esophagitis / Am J Gastroenterol 108:535~543
Dunbar KB / 2016 / Association of acute gastroesophageal reflux disease with esophageal histologic changes / JAMA 315:2104~2112
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