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논문 기본 정보

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학술저널
저자정보
Ga Hee Kim (Department of Gastroenterology University of Ulsan College of Medicine Seoul Korea) 정기욱 (Department of Gastroenterology University of Ulsan College of Medicine Seoul Korea) Hwoon-Yong Jung (Department of Gastroenterology University of Ulsan College of Medicine Seoul Korea) Kee Don Choi (Department of Gastroenterology University of Ulsan College of Medicine Seoul Korea) JungBok Lee (Department of Clinical Epidemiology and Biostatistics University of Ulsan College of Medicine Seoul) Young Soo Park (Department of Pathology University of Ulsan College of Medicine Seoul Korea) So-Woon Kim (Department of Pathology University of Ulsan College of Medicine Seoul Korea) Jeong Hoon Lee (Department of Gastroenterology University of Ulsan College of Medicine Seoul Korea) Do Hoon Kim (Department of Gastroenterology University of Ulsan College of Medicine Seoul Korea) Ji Yong Ahn (Department of Gastroenterology University of Ulsan College of Medicine Seoul Korea) Ho June Song (Department of Gastroenterology University of Ulsan College of Medicine Seoul Korea) Gin Hyug Lee (Department of Gastroenterology University of Ulsan College of Medicine Seoul Korea) Jin-Ho Kim (Department of Gastroenterology University of Ulsan College of Medicine Seoul Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.2
발행연도
2018.1
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248 - 254 (7page)

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Background/Aims The prevalence of eosinophilic esophagitis (EoE) is reportedly increasing in Western countries. However, its prevalence in Korea remains unknown. We investigated the diagnostic trends and clinical characteristics of EoE in Korea. Methods Using an endoscopic database maintained at a tertiary care center, we retrospectively reviewed the biopsy reports regarding 18 399 biopsy specimens collected from all patients who underwent esophagogastroduodenoscopy and esophageal biopsy at this facility between 2006 and 2014. The presence of more than 15 eosinophils per high-power field with symptoms related to esophageal dysfunction was considered to indicate EoE. Results A total of 37 patients (male:female ratio, 29:8; mean age, 44.0 ± 13.0 years) were diagnosed with EoE. These patients presented with dysphagia (21.6%), epigastric pain (21.6%), heartburn (24.3%), and other symptoms (32.4%). Typical endoscopic appearance of EoE was noted in 33 cases (89.1%) and included linear furrows in 24 cases (64.8%), ringed esophagus in 10 cases (27.0%), and white exudates in 11 cases (29.7%). The median eosinophilic count was 25 per high-power field (interquartile range, 20–70). Notable histopathological findings included eosinophilic microabscesses in 21 cases (56.7%). The diagnosis rate of EoE was found to have increased from 2006 and to 2014 (P-value < 0.001 by the Cochran-Armitage trend test). Conclusions The number of patients with EoE appears to have increased significantly over the 9-year period investigated, while the number of endoscopic investigations increased only marginally. Greater awareness of EoE and the role of esophageal biopsies should be considered.

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참고문헌 (20)

참고문헌 신청
Liacouras CA / 2011 / Eosinophilic esophagitis: updated consensus recommendations for children and adults / J Allergy Clin Immunol 128:3~20 Crossref Remedios M / 2006 / Eosinophilic esophagitis in adults: clinical, endoscopic, histologic findings, and response to treatment with fluticasone propionate / Gastrointest Endosc 63:3~12 Crossref Ronkainen J / 2007 / Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the population-based Kalixanda study / Gut 56:615~620 Crossref Shi YN / 2012 / Prevalence, clinical manifestations and endoscopic features of eosinophilic esophagitis: a pathological review in China / J Dig Dis 13:304~309 Crossref Tomomatsu Y / 2013 / Clinical features of eosinophilic esophagitis: ten Japanese cases / Dig Endosc 25:117~124 google schola

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