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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 852 - 859 (8page)
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Background/Aims: To investigate the use of measurements of liver stiffness (LS) by two-dimensional real-time shear wave elastography (SWE) for predicting the development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Methods: We retrospectively collected data on 291 enrolled patients with CHB whose LS had been measured using SWE. Results: The mean age of the patients was 46.8 years; males predominated (67%), and 40 of the patients (14%) had clinical cirrhosis. Among the patients, 165 (56.7%) received antiviral treatment. The median LS value was 7.4 kPa, and the median follow-up period was 35.8 months (range, 3.0 to 52.8 months). During follow-up, HCC developed in 13 patients (4.5%), and the cumulative incidence rates of HCC at 1, 2, and 4 years were 1.1%, 3.6%, and 8.4%, respectively. Based on a multivariate analysis, older age (≥50 years) and higher LS value (≥10 kPa) were independently associated with the risk of developing HCC (hazard ratio [HR], 4.53, p=0.023; and HR, 4.08, p=0.022). The cumulative incidence rate of HCC was significantly higher in patients with higher LS values (≥10 kPa) than in those with lower LS values (<10 kPa) (p=0.001). Conclusions: Increased LS measured by SWE at any time point regardless of antiviral treatment is associated with an increased risk of HCC in patients with CHB.
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참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)
Bedossa P / 2003 / Sampling variability of liver fibrosis in chronic hepatitis C / Hepatology 38 : 1449 ~ 1457
Bravo AA / 2001 / Liver biopsy / N Engl J Med 344 : 495 ~ 500
Bruix J / 2011 / American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update / epatology 53 : 1020 ~ 1022
Deffieux T / 2015 / Investigating liver stiffness and viscosity for fibrosis, steatosis and activity staging using shear wave elastography / J Hepatol 62 : 317 ~ 324
Bedossa P / 2003 / Sampling variability of liver fibrosis in chronic hepatitis C / Hepatology 38 : 1449 ~ 1457
Bravo AA / 2001 / Liver biopsy / N Engl J Med 344 : 495 ~ 500
Bruix J / 2011 / American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update / epatology 53 : 1020 ~ 1022
Deffieux T / 2015 / Investigating liver stiffness and viscosity for fibrosis, steatosis and activity staging using shear wave elastography / J Hepatol 62 : 317 ~ 324
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