지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 41 - 47 (7page)
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초록· 키워드
오류제보하기
Background/Aims: Cytapheresis (CAP) is a novel
strategy for ulcerative colitis (UC). However, there is
insufficient data on the long-term outcome of UC patients
who achieve remission by CAP. This study involved
patients with severe UC who refracted to intravenous
(iv) corticosteroid. Methods: Forty-seven UC
patients who had received CAP therapy for the first
time within 1 year after UC diagnosis were followed
for 36 months. One of the inclusion criteria was a clinical
activity index (CAI) of ≥7 points at the end of a
2-week iv course of corticosteroid therapy. CAP therapy
consisted of ten sessions over 10 weeks. Results:
CAP induced clinical remission (CAI≤4) in 70.2% patients
(33/47). The number of submissions for colectomy
was higher for severe UC at entry (CAI≥12,
n=25) than for moderately severe UC at entry (7≤CAI
＜12, p=15; p＜0.02). The cumulative rates of avoiding
surgery and relapse were 54.5% and 24.2%, respectively,
at 36 months in patients who responded to
CAP therapy. This was similar to that of iv cyclosporine
reported recently. Conclusions: This study
suggest that CAP is an effective therapy in patients
who are refractory to conventional medications including
iv corticosteroid. Increased remission rates should
be expected in refractory patients with moderately severe
UC.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Allison MC / 1998 / Inflammatory bowel disease / Mosby : 9 ~ 95
Campbell S / 2005 / Ciclosporin use in acute ulcerative colitis: a long-term experience / Eur J Gastroenterol Hepatol 17 : 79 ~ 84
Cohen RD / 1999 / Intravenous cyclosporin in ulcerative colitis: a five-year experience / Am J Gastroenterol 94 : 1587 ~ 1592
Dome?nech E / 2002 / Azathioprine without oral cyclosporine in the long-term maintenance of remission induced by intravenous cyclosporine in severe, steroid-refractory ulcer
D’Haens G / 2001 / Intravenous cyclosporine for severe attacks of ulcerative colitis / Gastroenterology 120 : 1323 ~ 1329
Campbell S / 2005 / Ciclosporin use in acute ulcerative colitis: a long-term experience / Eur J Gastroenterol Hepatol 17 : 79 ~ 84
Cohen RD / 1999 / Intravenous cyclosporin in ulcerative colitis: a five-year experience / Am J Gastroenterol 94 : 1587 ~ 1592
Dome?nech E / 2002 / Azathioprine without oral cyclosporine in the long-term maintenance of remission induced by intravenous cyclosporine in severe, steroid-refractory ulcer
D’Haens G / 2001 / Intravenous cyclosporine for severe attacks of ulcerative colitis / Gastroenterology 120 : 1323 ~ 1329
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