지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 674 - 683 (10page)
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초록· 키워드
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Background/Aims: Noninvasive liver fibrosis evaluation was performed in patients with nonalcoholic fatty liver disease (NAFLD). We used a quantitative method based on the hepatic volume acquired from gadoxetate disodium-enhanced (Gd-EOB-DTPA-enhanced) magnetic resonance imaging (MRI) for diagnosing advanced fibrosis in patients with NAFLD. Methods: A total of 130 patients who were diagnosed with NAFLD and underwent Gd-EOB-DTPA-enhanced MRI were retrospectively included. Histological data were available for 118 patients. Hepatic volumetric parameters, including the left hepatic lobe to right hepatic lobe volume ratio (L/R ratio), were measured. The usefulness of the L/R ratio for diagnosing fibrosis ≥F3–4 and F4 was assessed using the area under the receiver operating characteristic (AUROC) curve. Multiple regression analysis was performed to identify variables (age, body mass index, serum fibrosis markers, and histological features) that were associated with the L/R ratio. Results: The L/R ratio demonstrated good performance in differentiating advanced fibrosis (AUROC, 0.80; 95% confidence interval, 0.72 to 0.88) from cirrhosis (AUROC, 0.87; 95% confidence interval, 0.75 to 0.99). Multiple regression analysis showed that only fibrosis was significantly associated with the L/R ratio (coefficient, 0.121; p<0.0001). Conclusions: The L/R ratio, which is not influenced by pathological parameters other than fibrosis, is useful for diagnosing cirrhosis in patients with NAFLD.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Adams LA / 2005 / The natural history of nonalcoholic fatty liver disease: a population-based cohort study / Gastroenterology 129 : 113 ~ 121
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med 346 : 1221 ~ 1231
Angulo P / 2010 / Long-term mortality in nonalcoholic fatty liver disease: is liver histology of any prognostic significance / Hepatology 51 : 373 ~ 375
Angulo P / 2015 / Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease / Gastroenterolog
Argo CK / 2009 / Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis / J Hepatol 51 : 371 ~ 379
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med 346 : 1221 ~ 1231
Angulo P / 2010 / Long-term mortality in nonalcoholic fatty liver disease: is liver histology of any prognostic significance / Hepatology 51 : 373 ~ 375
Angulo P / 2015 / Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease / Gastroenterolog
Argo CK / 2009 / Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis / J Hepatol 51 : 371 ~ 379
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