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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background and Purpose Non-contrast brain computed tomography (NCCT) remains the most common imaging modality employed to select patients for thrombolytic therapy in acute ischemic stroke. The current study used the Alberta Stroke Program Early CT Score (ASPECTS) to identify early ischemic changes on brain NCCT imaging with the aim to investigate whether a relationship exists between time from symptoms onset to NCCT with the presence of early ischaemic change quantified by ASPECTS.
Methods We studied 1,329 ischemic stroke patients who had NCCT within 8 hours of stroke onset.
Patients were assessed to see if they had any ASPECTS lesion and if the rate of patients with a lesion increased with time using logistic regression.
Results 30% patients had an ASPECTS <10 within the first 3 hours from symptom onset. Within the first 3 hours, the odds for a CT change (ASPECTS <10) per minute of time was 1.00 with 95% confidence interval (CI) (0.99 to 1.00) (P=0.266). After 3 hours, there was a significant increase in odds of ASPECTS <10 with increasing time. The odds of being ASPECTS positive increased 1% (odds ratio=1.01) per 1 minute of time with 95% CI (1.00 to 1.01) (P=0.002).
Conclusions We have identified that prior to first 3 hours of stroke there was no effect of time on odds of CT ischemic change; after the first 3 hours of stroke the odds increased with increasing time to CT scan. The occurrence of early ischemic change may be a marker of time from stroke onset rather than severity.
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참고문헌 (33)
참고문헌 신청
Tei H / 2010 / Posterior circulation ASPECTS on diffusion-weighted MRI can be a powerful marker for predicting functional outcome / J Neurol 257:767~773
CT/DWI early ischemic changes
IMS II Trial Investigators / 2007 / The interventional management of stroke (IMS) II study / Stroke 38:2127~2135
Miteff F / 2009 / The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke / Brain 132:2231~2238
Bivard A / 2015 / Perfusion computed tomography to assist decision making for stroke thrombolysis / Brain 138:1919~1931
CT/DWI early ischemic changes
IMS II Trial Investigators / 2007 / The interventional management of stroke (IMS) II study / Stroke 38:2127~2135
Miteff F / 2009 / The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke / Brain 132:2231~2238
Bivard A / 2015 / Perfusion computed tomography to assist decision making for stroke thrombolysis / Brain 138:1919~1931
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