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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 138 - 143 (6page)
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이 논문의 연구 히스토리 (4)
2017
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Ovariectomy-induced bone loss is related to an increased deposition of osteoclasts on bone surfaces. We reported that the 36-amino-acid-long neuropeptide Y (NPY) could mobilize hematopoietic stem/progenitor cells (HSPCs) from the bone marrow to the peripheral blood by regulating HSPC maintenance factors and that mobilization of HSPCs ameliorated low bone density in an ovariectomy-induced osteoporosis mouse model by reducing the number of osteoclasts. Here, we demonstrated that new NPY peptides, recombined from the cleavage of the full-length NPY, showed better functionality for HSPC mobilization than the full-length peptide. These recombinant peptides mediated HSPC mobilization with greater efficiency by decreasing HSPC maintenance factors.
Furthermore, treatment with these peptides reduced the number of osteoclasts and relieved ovariectomy-induced bone loss in mice more effectively than treatment with full-length NPY. Therefore, these results suggest that peptides recombined from full-length NPY can be used to treat osteoporosis.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bae JS / 2005 / Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice / Hum Gene Ther 16:1006~1011
Arai F / 2004 / Tie2/angiopoietin-1 signaling regulates hematopoietic stem cells quiescence in the bone marrow niche / Cell 118 : 149 ~ 161
Butler JM / 2010 / Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells / Cell Stem Cell 6 : 251 ~ 264
Ding L / 2012 / Endothelial and perivascular cells maintain haematopoietic stem cells / Nature 481 : 457 ~ 462
Ehninger A / 2011 / The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in / J Exp Med 208 : 421
Arai F / 2004 / Tie2/angiopoietin-1 signaling regulates hematopoietic stem cells quiescence in the bone marrow niche / Cell 118 : 149 ~ 161
Butler JM / 2010 / Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells / Cell Stem Cell 6 : 251 ~ 264
Ding L / 2012 / Endothelial and perivascular cells maintain haematopoietic stem cells / Nature 481 : 457 ~ 462
Ehninger A / 2011 / The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in / J Exp Med 208 : 421
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