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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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Strategies for efficient osteogenic differentiation and bone formation from stem cells would have clinical applications in treating nonunion fracture healing. Many researchers have attempted to develop adjuvants as specific stimulators of bone formation for therapeutic use in patients with bone resorption. Therefore, development of specific stimulators of bone formation has therapeutic significance in the treatment of osteoporosis. To date, investigations of the mature forms of bone morphogenetic proteins (BMPs) have focused on regulation of bone generation. However, we previously identified new peptides from the immature precursor of BMP, and further analysis of these proteins should be performed. In this study, we identified a new peptide called bone-forming peptide-2 (BFP-2), which has stronger osteogenic differentiation-promoting activity than BMP-7. BFP-2 treatment of multipotent bone marrow stromal cells (BMSCs) induced expression of active alkaline phosphatase. In addition, BFP-2 enhanced CD44 and CD51 expression levels and increased Ca2+ content in BMSCs. Moreover, radiography at 8 weeks revealed that animals that had received transplants of BFP-2-treated BMSCs showed substantially increased bone formation compared with animals that had received BMSCs treated with BMP-7. Our findings indicate that BFP-2 may be useful in the development of adjuvant therapies for bone-related diseases.
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참고문헌 (19)
참고문헌 신청
Chen CH / 2005 / Green tea catechin enhances osteogenesis in a bone marrow mesenchymal stem cell line / Osteoporos Int 16 : 2039 ~ 2045
Chen L / 2010 / Insulin-like growth factor 2(IGF-2)potentiates BMP-9-induced osteogenic differentiation and bone formation / J Bone Miner Res 25 : 2447 ~ 2459
Dahir GA / 2000 / Pluripotential mesenchymal cells repopulate bone marrow and retain osteogenic properties / Clin Orthop Relat Res 379 : S134 ~ S145
Damoulis PD / 2007 / Osteogenic differentiation of human mesenchymal bone marrow cells in silk scaffolds is regulated by nitric oxide / Ann NY Acad Sci 1117 : 367 ~ 376
Gao X / 2014 / A comparison of bone regeneration with human mesenchymal stem cells and musclederived stem cells and the critical role of BMP / Biomaterials 35 : 6859 ~ 6870
Chen L / 2010 / Insulin-like growth factor 2(IGF-2)potentiates BMP-9-induced osteogenic differentiation and bone formation / J Bone Miner Res 25 : 2447 ~ 2459
Dahir GA / 2000 / Pluripotential mesenchymal cells repopulate bone marrow and retain osteogenic properties / Clin Orthop Relat Res 379 : S134 ~ S145
Damoulis PD / 2007 / Osteogenic differentiation of human mesenchymal bone marrow cells in silk scaffolds is regulated by nitric oxide / Ann NY Acad Sci 1117 : 367 ~ 376
Gao X / 2014 / A comparison of bone regeneration with human mesenchymal stem cells and musclederived stem cells and the critical role of BMP / Biomaterials 35 : 6859 ~ 6870
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