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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 115 - 120 (6page)
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Tight junction protein 1 (TJP1), a component of tight junction,has been reported to play a role in protein networks as anadaptor protein, and TJP1 expression is altered during tumordevelopment. Here, we found that TJP1 expression was increasedat the RNA and protein levels in TGF-β-stimulatedlung cancer cells, A549. SB431542, a type-I TGF-β receptorinhibitor, as well as SB203580, a p38 kinase inhibitor, significantlyabrogated the effect of TGF-β on TJP1 expression.
Diphenyleneiodonium, an NADPH oxidase inhibitor, also attenuatedTJP1 expression in response to TGF-β in lung cancercells. When TJP1 expression was reduced by shRNA lentiviralparticles in A549 cells (A549-sh TJP1), wound healing wasmuch lower than in cells infected with control viral particles.
Taken together, these data suggest that TGF-β enhances TJP1expression, which may play a role beyond structural supportin tight junctions during cancer development.
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참고문헌 (30)
참고문헌 신청
Halder SK / 1542 / A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers / Neoplasia 7:509~521
Hiraga R / 2013 / Nox4-derived ROS signaling contributes to TGF-beta-induced epithelial-mesenchymal transition in pancreatic cancer cells / Anticancer Res 33:4431~4438
Balda MS / 2000 / The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2expression / EMBO J 19:2024~2033
Brysse A / 2012 / Regulation of CXCL8/IL-8 expression by zonula occludens-1 in human breast cancer cells / Mol Cancer Res 10:121~132
Xu J / 2012 / ZO-1 regulates Erk, Smad1/5/8, Smad2, and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells / Stem Cells 30:1885~1900
Hiraga R / 2013 / Nox4-derived ROS signaling contributes to TGF-beta-induced epithelial-mesenchymal transition in pancreatic cancer cells / Anticancer Res 33:4431~4438
Balda MS / 2000 / The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2expression / EMBO J 19:2024~2033
Brysse A / 2012 / Regulation of CXCL8/IL-8 expression by zonula occludens-1 in human breast cancer cells / Mol Cancer Res 10:121~132
Xu J / 2012 / ZO-1 regulates Erk, Smad1/5/8, Smad2, and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells / Stem Cells 30:1885~1900
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