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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 462 - 467 (6page)
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A previous study of ours indicated that Drosophila flightless-1 controls lipid metabolism, and that there is an accumulation of triglycerides in flightless-1 (fliI)-mutant flies, where this mutation triggers metabolic stress and an obesity phenotype. Here, with the aim of characterizing the function of FliI in metabolism, we analyzed the levels of gene expression and metabolites in fliI-mutant flies. The levels of enzymes related to glycolysis, lipogenesis, and the pentose phosphate pathway increased in fliI mutants; this result is consistent with the levels of metabolites corresponding to a metabolic pathway. Moreover, high-throughput RNA sequencing revealed that Drosophila FliI regulates the expression of genes related to biological processes such as chromosome organization, carbohydrate metabolism, and immune reactions. These results showed that Drosophila FliI regulates the expression of metabolic genes, and that dysregulation of the transcription controlled by FliI gives rise to metabolic stress and problems in the development and physiology of Drosophila.
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참고문헌 (31)
참고문헌 신청
Campbell HD / 1993 / The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans / Proc Natl Acad Sci U S A 90:11386~11390
Archer SK / 2004 / The flightless I protein and the gelsolin family in nuclear hormone receptor-mediated signalling / Biochem Soc Trans 32:940~942
Ghoshdastider U / 2013 / The expanding superfamily of gelsolin homology domain proteins / Cytoskeleton (Hoboken) 70:775~795
Nag S / 2013 / Gelsolin: the tail of a molecular gymnast / Cytoskeleton (Hoboken) 70:360~384
Cowin AJ / 2007 / Flightless I deficiency enhances wound repair by increasing cell migration and proliferation / J Pathol 211:572~581
Archer SK / 2004 / The flightless I protein and the gelsolin family in nuclear hormone receptor-mediated signalling / Biochem Soc Trans 32:940~942
Ghoshdastider U / 2013 / The expanding superfamily of gelsolin homology domain proteins / Cytoskeleton (Hoboken) 70:775~795
Nag S / 2013 / Gelsolin: the tail of a molecular gymnast / Cytoskeleton (Hoboken) 70:360~384
Cowin AJ / 2007 / Flightless I deficiency enhances wound repair by increasing cell migration and proliferation / J Pathol 211:572~581
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