지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 11 (11page)
이용수
초록· 키워드
오류제보하기
The endoplasmic reticulum (ER) stress response is an adaptive mechanism that is activated upon disruption of ER homeostasis and protects the cells against certain harmful environmental stimuli. However, critical and prolonged cell stress triggers cell death. In this study, we demonstrate that Flightless-1 (FliI) regulates ER stress-induced apoptosis in colon cancer cells by modulating Ca2+ homeostasis. FliI was highly expressed in both colon cell lines and colorectal cancer mouse models. In a mouse xenograft model using CT26 mouse colorectal cancer cells, tumor formation was slowed due to elevated levels of apoptosis in FliI-knockdown (FliI-KD) cells. FliI-KD cells treated with ER stress inducers, thapsigargin (TG), and tunicamycin exhibited activation of the unfolded protein response (UPR) and induction of UPRrelated gene expression, which eventually triggered apoptosis. FliI-KD increased the intracellular Ca2+ concentration, and this upregulation was caused by accelerated ER-to-cytosolic efflux of Ca2+. The increase in intracellular Ca2+ concentration was significantly blocked by dantrolene and tetracaine, inhibitors of ryanodine receptors (RyRs). Dantrolene inhibited TG-induced ER stress and decreased the rate of apoptosis in FliI-KD CT26 cells. Finally, we found that knockdown of FliI decreased the levels of sorcin and ER Ca2+ and that TG-induced ER stress was recovered by overexpression of sorcin in FliI-KD cells. Taken together, these results suggest that FliI regulates sorcin expression, which modulates Ca2+ homeostasis in the ER through RyRs. Our findings reveal a novel mechanism by which FliI influences Ca2+ homeostasis and cell survival during ER stress.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Potential involvement of Drosophila flightless-1 in carbohydrate metabolism
BMB Reports
2018 .01
-
Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes
Experimental and Molecular Medicine
2017 .01
-
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling
Experimental and Molecular Medicine
2021 .02
-
Potassium homeostasis-disturbing polypeptide induced ER stress-mediated apoptosis
한국고분자학회 학술대회 연구논문 초록집
2019 .04
-
Unfolded Protein Response Monitoring System for Intuitive Identification of ER Stress in CHO Cells
한국생물공학회 학술대회
2021 .04
-
Er 3+ doped Y3Al5O12 단결정의 core 영역 및 광학적 특성
한국결정성장학회지
2015 .01
-
ER Stress-driven BCL-2 Overexpression Inhibits Cell Death in CHO Cells
한국생물공학회 학술대회
2020 .10
-
원자층 증착 Er₂O₃와 Er doped HfO₂
대한전자공학회 학술대회
2015 .06
-
Structural characterization of calmodulin like domain of ryanodine receptor type 1
Journal of the Korean Magnetic Resonance Society
2015 .01
-
Fumonisin B₁ Exerts Its Toxic Effect on Spleen Tissue by Oxidative Stress Induced ER Stress Pathway
한국생물공학회 학술대회
2015 .04
-
Uniform CA와 90/150 Hybrid CA의 합성
한국전자통신학회 논문지
2016 .01
-
ER4043 및 5183 필러 와이어를 이용하여 TIG 용접한 A6061-T6 알루미늄 판재의 미세조직 관찰 및 피로특성
대한용접학회 특별강연 및 학술발표대회 개요집
2017 .11
-
The Enhancement of Upconversion Luminescence of Gd2O3:Yb,Er Nanoparticles by Ca2+ Codoping for Temperature Sensing at Room and High Temperatures
NANO
2019 .01
-
The inhibition of chloride intracellular channel 1 enhances Ca2+ and reactive oxygen species signaling in A549 human lung cancer cells
Experimental and Molecular Medicine
2019 .01
-
Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity
Experimental and Molecular Medicine
2019 .01
-
Anti-Endoplasmic Reticulum Stress induced Apoptosis by Silkworm Storage Protein 1, SP1
한국생물공학회 학술대회
2018 .10
-
Nucleotide-binding oligomerization domain protein 2 attenuates ER stress-induced cell death in vascular smooth muscle cells
BMB Reports
2019 .01
-
Harnessing CRISPR-Cas adaptation for RNA recording and beyond
BMB Reports
2024 .01
-
Celecoxib-mediated activation of endoplasmic reticulum stress induces de novo ceramide biosynthesis and apoptosis in hepatoma HepG2 cells
BMB Reports
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0