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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 217 - 222 (6page)
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초록· 키워드
오류제보하기
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death worldwide.
Distant metastasis is a major cause of mortality in CRC.
MicroRNAs (miRNAs) are small non-coding RNA molecules involved in the post-transcriptional and translational regulation of gene expression. Many miRNAs are aberrantly expressed in cancer and influence tumor progression. Accumulating studies suggest that multiple miRNAs are actively involved in the CRC metastasis process. Thus, we aim to introduce the role of mi- RNAs in multi-steps of CRC metastasis, including cancer cell invasion, intravasation, circulation, extravasation, colonization, angiogenesis, and epithelial-mesenchymal transition (EMT). Moreover, we suggest the potential application of miRNAs as biomarkers for CRC patients with metastasis.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Akao Y / 2006 / let-7 microRNA functions as a potential growth suppressor in human colon cancer cells / Biol Pharm Bull 29 : 903 ~ 906
Asangani IA / 2008 / MicroRNA-21(miR-21)post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cance
Bartel DP / 2009 / MicroRNAs : target recognition and regulatory functions / Cell 136 : 215 ~ 233
Chang TC / 2007 / Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis / Mol Cell 26 : 745 ~ 752
Chen X / 2009 / Role of miR-143 targeting KRAS in colorectal tumorigenesis / Oncogene 28 : 1385 ~ 1392
Asangani IA / 2008 / MicroRNA-21(miR-21)post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cance
Bartel DP / 2009 / MicroRNAs : target recognition and regulatory functions / Cell 136 : 215 ~ 233
Chang TC / 2007 / Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis / Mol Cell 26 : 745 ~ 752
Chen X / 2009 / Role of miR-143 targeting KRAS in colorectal tumorigenesis / Oncogene 28 : 1385 ~ 1392
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