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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국자기공명학회 Journal of the Korean Magnetic Resonance Society Journal of the Korean Magnetic Resonance Society 제20권 제2호
- 발행연도
- 2016.1
- 수록면
- 46 - 49 (4page)
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초록· 키워드
오류제보하기
MiRNA-155, upregulated in various cancers, is one of the miRNAs that suppress apoptosis of human cancer. Thus, inhibition of the maturation of miRNA-155 could be an effective way to induce apoptotic cancer cell death. The apical stem-loop of the pre-miRNA-155 has been known as a Dicer biding site for RNA cleavage. Here, to understand the molecular basis of the tertiary interaction between pre-miRNA-155 with Dicer, we characterize the structure of the apical stem-loop of pre-miRNA-155 using NMR spectroscopy. The RNA has a stem-bulge-stem-loop-stem structure, which is consist of G-C Watson-Crick and G-U Wobble base pairs. The assignments of imino- protons were further confirmed by 2D 15N-1H HSQC NMR spectrum. The NMR parameters obtained in this study can be further used to investigate the tertiary interaction between pre-miRNA-155 and other biomolecules such as protein, nucleic acids, or small chemicals which might be used to control the apoptosis of cancer.
목차
등록된 정보가 없습니다.
참고문헌 (8)
참고문헌 신청
M. Ha / 2014 / Nat. Rev. Mol. Cell Biol 15:509
A. Esquela-Kerscher / 2006 / Nat. Rev. Cancer 6:259
J. Pai / 2016 / J. Am. Chem. Soc 138:857
김낙균 / 2014 / NMR methods for structural analysis of RNA: a Review / Journal of the Korean Magnetic Resonance Society 18(1):5~9
김원제 / 2015 / Proper NMR methods for studying RNA thermometers / Journal of the Korean Magnetic Resonance Society 19(3):143~148
A. Esquela-Kerscher / 2006 / Nat. Rev. Cancer 6:259
J. Pai / 2016 / J. Am. Chem. Soc 138:857
김낙균 / 2014 / NMR methods for structural analysis of RNA: a Review / Journal of the Korean Magnetic Resonance Society 18(1):5~9
김원제 / 2015 / Proper NMR methods for studying RNA thermometers / Journal of the Korean Magnetic Resonance Society 19(3):143~148
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