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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 122 - 127 (6page)
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Engineered bone tissue is thought to be the ideal alternative for bone grafts in the treatment of related bone diseases. BMP9 has been demonstrated as one of the most osteogenic factors, and enhancement of BMP9-induced osteogenesis will greatly accelerate the development of bone tissue engineering. Here, we investigated the effect of insulin-like growth factor 1 (IGF1) on BMP9-induced osteogenic differentiation, and unveiled a possible molecular mechanism underling this process. We found that IGF1 and BMP9 are both detectable in mesenchymal stem cells (MSCs). Exogenous expression of IGF1 potentiates BMP9-induced alkaline phosphatase (ALP), matrix mineralization, and ectopic bone formation. Similarly, IGF1 enhances BMP9-induced endochondral ossification. Mechanistically, we found that IGF1 increases BMP9-induced activation of BMP/Smad signaling in MSCs. Our findings demonstrate that IGF1 can enhance BMP9-induced osteogenic differentiation in MSCs, and that this effect may be mediated by the enhancement of the BMP/Smad signaling transduction triggered by BMP9.
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참고문헌 (36)
참고문헌 신청
Harada N / 2014 / Bone regeneration in a massive rat femur defect through endochondral ossification achieved with chondrogenically differentiated MSCs in a degradable scaffold / Biomaterials 35:7800~7810
Amini AR / 2012 / Bone tissue engineering: recent advances, challenges / Crit Rev Biomed Eng 40:363~408
Huang J / 2014 / The role of COX-2 in mediating the effect of PTEN on BMP9 induced osteogenic differentiation in mouse embryonic fibroblasts / Biomaterials 35:9649~9659
Kang Q / 2004 / Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery / Gene Ther 11:1312~1320
Khosla S / 2008 / Building bone to reverse osteoporosis, repair fractures / J Clin Invest 118:421~428
Amini AR / 2012 / Bone tissue engineering: recent advances, challenges / Crit Rev Biomed Eng 40:363~408
Huang J / 2014 / The role of COX-2 in mediating the effect of PTEN on BMP9 induced osteogenic differentiation in mouse embryonic fibroblasts / Biomaterials 35:9649~9659
Kang Q / 2004 / Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery / Gene Ther 11:1312~1320
Khosla S / 2008 / Building bone to reverse osteoporosis, repair fractures / J Clin Invest 118:421~428
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