지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 171 - 181 (11page)
이용수
초록· 키워드
오류제보하기
The effect of vascular endothelial growth factor (VEGF) combined with bone morphogenetic protein-2 (BMP-2) for bone regeneration is still controversial as to whether or not VEGF has a synergistic or additive effect. This study attempted to evaluate the synergistic effect of VEGF and BMP-2 compared to BMP-2 alone for maxillary alveolar bone regeneration using collagen sponge/hydrogel complex sheets in a canine model. After mixing BMP-2 and VEGF with a hyaluronic acid-based hydrogel (HAH), the collagen sponge/hydrogel complex was transplanted into maxillary alveolar bone defects (n=14) after the extraction of canine upper first molars on both sides. Bone regeneration was evaluated in three groups (control group without growth factors, experimental groups I and II with BMP-2 alone and BMP-2 and VEGF, respectively) using micro-computed tomography and histological staining. The total amount of new bone formations and bone mineral density were significantly higher in the group with BMP-2 only and the group with BMP-2 combined with VEGF than it in the control group. The area with positive staining of von Willebrand factor bone defect was significantly greater in the group with BMP-2 only and with dual growth factors than the control. BMP-2 released from the HAH promoted new bone formation. However, the combination of BMP-2 and VEGF did not show a synergistic or additive effect on bone regeneration at canine maxillary alveolar bone defects.
목차
등록된 정보가 없습니다.
참고문헌 (47)
참고문헌 신청
Tarnow DP / 2010 / Maxillary sinus augmentation using recombinant bone morphogenetic protein-2/acellular collagen sponge in combination with a mineralized bone replacement graft: a report of three cases / Int J Periodontics Restorative Dent 30:139~149
Hayashi K / 2007 / Development of new drug delivery system for implant bone augmentation using a basic fibroblast growth factor-gelatin hydrogel complex / Dent Mater J 26:170~177
Kim J / 2007 / Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2and human mesenchymal stem cells / Biomaterials 28:1830~1837
Deng Y / 2014 / Repair of canine medial orbital bone defects with miR-31-modified bone marrow mesenchymal stem cells / Invest Ophthalmol Vis Sci 55:6016~6023
Samee M / 2008 / Bone morphogenetic protein-2(BMP-2)and vascular endothelial growth factor(VEGF)transfection to human periosteal cells enhances osteoblast differentiation and bone formation / J Pharmacol Sci 108:18~31
Hayashi K / 2007 / Development of new drug delivery system for implant bone augmentation using a basic fibroblast growth factor-gelatin hydrogel complex / Dent Mater J 26:170~177
Kim J / 2007 / Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2and human mesenchymal stem cells / Biomaterials 28:1830~1837
Deng Y / 2014 / Repair of canine medial orbital bone defects with miR-31-modified bone marrow mesenchymal stem cells / Invest Ophthalmol Vis Sci 55:6016~6023
Samee M / 2008 / Bone morphogenetic protein-2(BMP-2)and vascular endothelial growth factor(VEGF)transfection to human periosteal cells enhances osteoblast differentiation and bone formation / J Pharmacol Sci 108:18~31
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
rhBMP-2-Conjugated Three-Dimensional-Printed Poly(l-lactide) Scaffold is an Effective Bone Substitute
조직공학과 재생의학
2023 .02
-
BMP-2 Concentration Effect on Bone Regeneration : In vitro and In vivo Studies Using PLGA Beads with Different BMP-2 Release Pattern
한국고분자학회 학술대회 연구논문 초록집
2015 .10
-
Bone Morphogenetic Protein (BMP)의 발견
BT NEWS
2015 .10
-
IGF1 potentiates BMP9-induced osteogenic differentiation in mesenchymal stem cells through the enhancement of BMP/Smad signaling
BMB Reports
2016 .01
-
Periimplant Bone Regeneration in Hydroxyapatite Block Grafts with Mesenchymal Stem Cells and Bone Morphogenetic Protein-2
조직공학과 재생의학
2016 .01
-
BMP-2 linked thermo-sensitive hydrogel for bone tissue engineering
한국고분자학회 학술대회 연구논문 초록집
2017 .04
-
BMP2-mediated Silica Deposition: An Effective Strategy for Bone Mineralization
한국생물공학회 학술대회
2022 .04
-
Controlled Release of Antibiotics and BMP-2 Using Gelatin Microspheres for Optimal Bone Regeneration
한국고분자학회 학술대회 연구논문 초록집
2023 .04
-
BMP-2-Immobilized Porous Microparticles for Improved Osteogenic Differentiation
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
골조직공학을 위한 BMP-2로 고정화된 3D 프린팅 PGA 지지체의 제조 및 특성평가
폴리머
2024 .07
-
Enhancement of Osseointegration of Artificial Ligament by Nano-Hydroxyapatite and Bone Morphogenic Protein-2 into the Rabbit Femur
조직공학과 재생의학
2016 .01
-
Functionalized Microparticles with Signaling Molecules and Stem Cells for Enhanced Bone Regeneration
한국고분자학회 학술대회 연구논문 초록집
2021 .10
-
Hybrid PLGA Scaffold with Bioactive PDRN/BMP2 Nanocomplex for Bone Regeneration using Human Fetal MSCs
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
BMP-2-Loaded GBR Membrane with Leaf-Stacked Structure for Bone Regeneration
한국고분자학회 학술대회 연구논문 초록집
2016 .04
-
Self-immobilization of BMP2 Knuckle Epitope Peptide (P4) in silica Particles via P4-mediated silica Deposition and Delivery to Bone Cells
한국생물공학회 학술대회
2023 .10
-
Bone-forming peptide-2 derived from BMP-7 enhances osteoblast differentiation from multipotent bone marrow stromal cells and bone formation
Experimental and Molecular Medicine
2017 .01
-
전리방사선이 조사된 쥐의 두개골상의 BMP-2 효용성 연구
한국방사선학회 논문지
2019 .01
-
Bone Morphogenic Protein-2-Conjugated Three-Dimensional-Printed Poly (L-Lactic Acid) (PLLA) Scaffold is likely Promising as an Effective Bone Substitute
조직공학과 재생의학
2023 .04
-
남강댐 상류유역 수질관리를 위한 BMPs의 다목적 최적화
한국물환경학회지
2018 .01
-
Sustained Release of BMP-2 from GBR Membrane with Leaf-Stacked Structure for Effective Bone Regeneration
한국고분자학회 학술대회 연구논문 초록집
2016 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0