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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 93 - 98 (6page)
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Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. In this review, we propose a mechanism that controls GSCs and their cell fate through selective activation, repression and mobilization of the specific mRNAs. This mechanism is acutely controlled by known signal transduction pathways (e.g., Notch signaling and Ras-ERK MAPK signaling pathways) and P granule (analogous to mammalian germ granule)-associated mRNA regulators (FBF-1, FBF-2, GLD-1, GLD-2, GLD-3, RNP-8 and IFE-1).
Importantly, all regulators are highly conserved in many multi-cellular animals. Therefore, GSCs from a simple animal may provide broad insight into vertebrate stem cells (e.g., hematopoietic stem cells) and their cell fate specification.
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참고문헌 (48)
참고문헌 신청
Spradling A / 2011 / Germline stem cells / Cold Spring Harb Perspect Biol 3:a002642
Datla US / 2014 / Role of PUF-8/PUF protein in stem cell control, sperm-oocyte decision, cell fate reprogramming / J Cell Physiol 10:1306~1311
Robert A. Kobet / 2014 / Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification / Biomolecules & Therapeutics 22(5):371~383
Kimble J / 2007 / Controls of germline stem cells, entry into meiosis, and the sperm/oocyte decision in Caenorhabditis elegans / Annu Rev Cell Dev Biol 23:405~433
Kimble J / 2007 / Controls of germline stem cells, entry into meiosis, , the sperm/oocyte decision in Caenorhabditis elegans / Annu Rev Cell Dev Biol 23:405~433
Datla US / 2014 / Role of PUF-8/PUF protein in stem cell control, sperm-oocyte decision, cell fate reprogramming / J Cell Physiol 10:1306~1311
Robert A. Kobet / 2014 / Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification / Biomolecules & Therapeutics 22(5):371~383
Kimble J / 2007 / Controls of germline stem cells, entry into meiosis, and the sperm/oocyte decision in Caenorhabditis elegans / Annu Rev Cell Dev Biol 23:405~433
Kimble J / 2007 / Controls of germline stem cells, entry into meiosis, , the sperm/oocyte decision in Caenorhabditis elegans / Annu Rev Cell Dev Biol 23:405~433
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