지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 197 - 198 (2page)
이용수
초록· 키워드
오류제보하기
Although three different research groups have reported successful derivations of human somatic cell nuclear transfer-derived embryonic stem cell (SCNT-ESC) lines using fetal, neonatal and adult fibroblasts, the extremely poor development of cloned embryos has hindered its potential applications in regenerative medicine. Recently, however, our group discovered that the severe methylation of lysine 9 in Histone H3 in a human somatic cell genome was a major SCNT reprogramming barrier, and the overexpression of KDM4A, a H3K9me3 demethylase, significantly improved the blastocyst formation of SCNT embryos. In particular, by applying this new approach, we were able to produce multiple SCNT-ES cell lines using oocytes obtained from donors whose eggs previously failed to develop to the blastocyst stage.
Moreover, the success rate was closer to 25%, which is comparable to that of IVF embryos, so that our new human SCNT method seems to be a practical approach to establishing a pluripotent stem cell bank for the general public as well as for individual patients.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Thin Film SCNT Characterization Fabricated by Pulsed Laser Deposition
한국정밀공학회 학술발표대회 논문집
2019 .10
-
Thickness Optimization of Thin-film SCNT Cathode for Low-temperature Solid Oxide Fuel Cells
한국정밀공학회 학술발표대회 논문집
2021 .11
-
The promotive effect of human induced pluripotent stem cell-conditioned medium on growth and migration of human skin cells
한국생물공학회 학술대회
2016 .10
-
확산 모형을 이용한 줄기 세포 기술의 수명 주기 분석 : 연구 단계를 중심으로
대한산업공학회지
2015 .10
-
Stem cell maintenance by manipulating signaling pathways: past, current and future
BMB Reports
2015 .01
-
이종이식 활용 돼지 생산을 위한 공여 세포의 특성 분석 및 CRISPR-Cpf1을 활용한 O Type 혈액형 형질전환 동물의 제작
동물자원연구
2023 .06
-
New insights into the epitranscriptomic control of pluripotent stem cell fate
Experimental and Molecular Medicine
2022 .10
-
Stem cells and reproduction
BMB Reports
2019 .01
-
돼지 난포액 유래 엑소좀 처리 공여란과 공여세포의 체세포복제란 발달율에 미치는 영향
한국산학기술학회 논문지
2024 .07
-
Development of culture strategies for stem cell maintenance and differentiation through regulation of cell behaviors
한국생물공학회 학술대회
2016 .04
-
Co-ordinated Generation of Ocular Cell Lineages from Pluripotent Stem Cells and its Application to Regenerative Medicine
한국생물공학회 학술대회
2019 .10
-
Efficient Reprogramming of Human Somatic Cells into Induced Pluripotent Stem Cells by Intracellular Delivery of RNA Nanoparticle
한국생물공학회 학술대회
2020 .10
-
Preparation of SCNT as a Cathode for Solid Oxide Fuel Cells by Pulsed Laser Deposition
한국정밀공학회 학술발표대회 논문집
2018 .10
-
Development of immunocompatible pluripotent stem cells via CRISPR-based human leukocyte antigen engineering
Experimental and Molecular Medicine
2019 .01
-
Modeling of Skeletal Development Using Human Pluripotent Stem Cells and Exploring the Gene Regulatory Networks
한국생물공학회 학술대회
2023 .04
-
Optimization of SCNT Cathode by Pulsed Laser Deposition for Thin-Film Solid Oxide Fuel Cells
한국정밀공학회 학술발표대회 논문집
2020 .09
-
Bioengineering Considerations for a Nurturing Way to Improve Expansion of Pluripotent Stem Cells
한국생물공학회 학술대회
2021 .10
-
Human induced pluripotent stem cell conditioned medium ameliorates skin damages via promoting proliferation and migration of dermal fibroblasts
한국생물공학회 학술대회
2018 .04
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
BT NEWS
2015 .10
-
Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation
Experimental and Molecular Medicine
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0