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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 376 - 381 (6page)
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Several lines of evidence have revealed that phosphorylation of amyloid precursor protein (APP) at Thr668 is involved in the pathogenesis of Alzheimer’s disease (AD). Okadaic acid (OA), a protein phosphatase-2A inhibitor, has been used in AD research models to increase tau phosphorylation and induce neuronal death. We previously showed that OA increased levels of APP and induced accumulation of APP in axonal swellings. In this study, we found that in OA-treated neurons, phosphorylation of APP at Thr668 increased and accumulated in axonal swellings by c-jun N-terminal kinase (JNK), and not by Cdk5 or ERK/MAPK. These results suggest that JNK may be one of therapeutic targets for the treatment of AD.
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참고문헌 (32)
참고문헌 신청
Gomez-Isla T / 1997 / Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease / Ann Neurol 41:17~24
Hardy J / 2002 / The amyloid hypothesis of Alzheimer's disease: progress, problems on the road to therapeutics / Science 297:353~356
Grundke-Iqbal I / 1986 / Abnormal phosphorylation of the microtubule-associated protein tau(tau)in Alzheimer cytoskeletal pathology / Proc Natl Acad Sci U S A 83:4913~4917
Tanimukai H / 2005 / Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease / Am J Pathol 166:1761~1771
Tachibana K / 1981 / Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria / J Am Chem Soc 103:2469~2471
Hardy J / 2002 / The amyloid hypothesis of Alzheimer's disease: progress, problems on the road to therapeutics / Science 297:353~356
Grundke-Iqbal I / 1986 / Abnormal phosphorylation of the microtubule-associated protein tau(tau)in Alzheimer cytoskeletal pathology / Proc Natl Acad Sci U S A 83:4913~4917
Tanimukai H / 2005 / Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease / Am J Pathol 166:1761~1771
Tachibana K / 1981 / Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria / J Am Chem Soc 103:2469~2471
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