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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 510 - 515 (6page)
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초록· 키워드
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Triglyceride (TG) accumulation causes macrophage cell death, which affects the development of atherosclerosis. Here, we examined whether caspase-2 is implicated in TG-induced macrophage cell death. We found that caspase-2 activity is increased in TG-treated THP-1 macrophages, and that inhibition of caspase-2 activity drastically inhibits TG-induced cell death. We previously reported that TG-induced macrophage cell death is triggered by caspase-1, and thus investigated the relationship between caspase-2 and caspase-1 in TG-induced macrophage cell death. Inhibition of caspase-2 activity decreased caspase-1 activity in TG-treated macrophages. However, caspase-1 inhibition did not affect caspase-2 activity, suggesting that caspase-2 is upstream of caspase-1. Furthermore, we found that TG induces activation of caspase-3, -7, -8, and -9, as well as cleavage of PARP. Inhibition of caspase-2 and -1 decreased TG-induced caspase-3, -7, -8, and -9 activation and PARP cleavage. Taken together, these results suggest that TG-induced macrophage cell death is mediated via the caspase-2/caspase-1/apoptotic caspases/PARP pathways.
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참고문헌 (30)
참고문헌 신청
Stefanis L / 1998 / Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity / J Neurosci 18:9204~9215
임재원 / 2014 / Triglyceride Up-regulates Expression of ABCG1 in PMA-induced THP-1 Macrophages Through Activation of JNK and p38 MAPK Pathways / 대한의생명과학회지 20(4):237~243
주동현 / 2016 / Biphasic activation of extracellular signal-regulated kinase (ERK) 1/2 in epidermal growth factor (EGF)-stimulated SW480 colorectal cancer cells / BMB Reports 49(4):220~225
Imre G / 2012 / Caspase-2 is an initiator caspase responsible for pore-forming toxinmediated apoptosis / EMBO J 31:2615~2628
조효상 / 2016 / Protective effects of Tat-NQO1 against oxidative stress-induced HT-22 cell damage, and ischemic injury in animals / BMB Reports 49(11):617~622
임재원 / 2014 / Triglyceride Up-regulates Expression of ABCG1 in PMA-induced THP-1 Macrophages Through Activation of JNK and p38 MAPK Pathways / 대한의생명과학회지 20(4):237~243
주동현 / 2016 / Biphasic activation of extracellular signal-regulated kinase (ERK) 1/2 in epidermal growth factor (EGF)-stimulated SW480 colorectal cancer cells / BMB Reports 49(4):220~225
Imre G / 2012 / Caspase-2 is an initiator caspase responsible for pore-forming toxinmediated apoptosis / EMBO J 31:2615~2628
조효상 / 2016 / Protective effects of Tat-NQO1 against oxidative stress-induced HT-22 cell damage, and ischemic injury in animals / BMB Reports 49(11):617~622
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