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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 305 - 310 (6page)
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초록· 키워드
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Toll-like receptors (TLRs) play a critical role in the innate immune response against pathogens. Each TLR recognizes specific pathogen-associated molecular patterns, after which they activate the adaptor protein MyD88 or TRIF-assembled signaling complex to produce immune mediators, including inflammatory cytokines and type I IFNs. Although the activation of TLR is important for host defense, its uncontrolled activation can damage the host. During the past decade, numerous studies have demonstrated that GSK3β is a key regulator of inflammatory cytokine production in MyD88-mediated TLR signaling via TLR2 and TLR4. Recently, GSK3β has also been implicated in the TRIF-dependent signaling pathway via TLR3. In this review, we describe current advances on the regulatory role of GSK3β in immune responses associated with various TLRs. A better understanding of the role of GSK3β in TLR signaling might lead to more effective anti-inflammatory interventions.
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참고문헌 (50)
참고문헌 신청
Medzhitov R / 1997 / Innate immunity:the virtues of a nonclonal system of recognition / Cell 91:295~298
Akira S / 2004 / Toll-like receptor signalling / Nat Rev Immunol 4:499~511
Akira S / 2006 / Pathogen recognition and innate immunity / Cell 124:783~801
Kawai T / 2010 / The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors / Nat Immunol 11:373~384
Kawagoe T / 2008 / Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 / Nat Immunol 9:684~691
Akira S / 2004 / Toll-like receptor signalling / Nat Rev Immunol 4:499~511
Akira S / 2006 / Pathogen recognition and innate immunity / Cell 124:783~801
Kawai T / 2010 / The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors / Nat Immunol 11:373~384
Kawagoe T / 2008 / Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 / Nat Immunol 9:684~691
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