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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.12
- 수록면
- 151 - 158 (8page)
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초록· 키워드
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Autophagy is a cellular process that degrades and recycles cytoplasmic organelles and macromolecules, which plays critical roles in cell survival and maintenance. Indeed, accumulating studies have shown that inactivation of autophagy genes generates defects in embryogenesis and tissue regeneration. The genome wide analysis showed many genes required for autophagy are highly upregulated in human keratinocytes stimulated by Poly (I:C). Using TLR3-siRNA, we found expression of autophagy-related genes is regulated by TLR3-mediated signaling pathway. Importantly, inhibition of autophagy using the class III PI3K inhibitor 3-methyladenine significantly decreases TLR3-induced genes including TLR3 and WNT7b. In particular, ATG5 specific inhibition blocks WNT7b expression in human keratinocytes in response to Poly (I:C). Thus, we suggest that autophagy is essential to regulate TLR3-mediated regeneration.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHODS
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2023-470-000309051