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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 220 - 225 (6page)
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초록· 키워드
오류제보하기
Antisense transcripts were initially identified as transcriptional noise, but have since been reported to play an important role in the quality control of miRNA functions. In this report, we tested the hypothesis that heterogeneous nuclear ribonucleoprotein K (hnRNPK) regulates miRNA function via competitive endogenous RNAs, such as pseudogenes, long non-coding RNAs, and antisense transcripts. Based on analyses of RNA sequencing data, the knockdown of hnRNPK decreased the antisense PTOV1-AS1 transcript which harbors five binding sites for miR-1207-5p. We identified heme oxygenase-1 (HO-1) mRNA as a novel target of miR-1207-5p by western blotting and Ago2 immunoprecipitation. The knockdown of hnRNPK or PTOV1-AS1 suppressed HO-1 expression by increasing the enrichment of HO-1 mRNA in miR-1207-5p-mediated miRISC. Downregulation of HO-1 by a miR-1207-5p mimic or knockdown of hnRNPK and PTOV1- AS1 inhibited the proliferation and clonogenic ability of HeLa cells. Taken together, our results demonstrate that hnRNPKregulated PTOV1-AS1 modulates HO-1 expression via miR- 1207-5p.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Ali F / 2009 / Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbe
Bartel DP / 2009 / MicroRNAs: target recognition and regulatory functions / Cell 136 : 215 ~ 233
Benedit P / 2001 / PTOV1, a novel protein overexpressed in prostate cancer containing a new class of protein homology blocks / Oncogene 20 : 1455 ~ 1464
Cesana M / 2013 / Deciphering the rules of ceRNA networks / Proc Natl Acad Sci U S A 110 : 7112 ~ 7113
Chau LY / 2015 / Heme oxygenase-1: emerging target of cancer therapy / J Biomed Sci 22 : 22 ~
Bartel DP / 2009 / MicroRNAs: target recognition and regulatory functions / Cell 136 : 215 ~ 233
Benedit P / 2001 / PTOV1, a novel protein overexpressed in prostate cancer containing a new class of protein homology blocks / Oncogene 20 : 1455 ~ 1464
Cesana M / 2013 / Deciphering the rules of ceRNA networks / Proc Natl Acad Sci U S A 110 : 7112 ~ 7113
Chau LY / 2015 / Heme oxygenase-1: emerging target of cancer therapy / J Biomed Sci 22 : 22 ~
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