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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
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- 학술저널
- 저자정보
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- 2015.1
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MicroRNAs (miRNAs), a class of small non-coding RNAs, mediate gene expression by either cleaving target mRNAs or inhibiting their translation. They have key roles in the tumorigenesis of several cancers, including non-small cell lung cancer (NSCLC). The aim of this study was to investigate the clinical significance of miR-638 in the evaluation of NSCLC patient prognosis in response to chemotherapy. First, we detected miR-638 expression levels in vitro in the culture supernatants of the NSCLC cell line SPC-A1 treated with cisplatin, as well as the apoptosis rates of SPC-A1. Second, serum miR-638 expression levels were detected in vivo by using nude mice xenograft models bearing SPC-A1 with and without cisplatin treatment. In the clinic, the serum miR-638 levels of 200 cases of NSCLC patients before and after chemotherapy were determined by quantitative real-time PCR, and the associations of clinicopathological features with miR-638 expression patterns after chemotherapy were analyzed. Our data helped in demonstrating that cisplatin induced apoptosis of the SPC-A1 cells in a dose- and time-dependent manner accompanied by increased miR-638 expression levels in the culture supernatants. In vivo data further revealed that cisplatin induced miR-638 upregulation in the serum derived from mice xenograft models, and in NSCLC patient sera, miR-638 expression patterns after chemotherapy significantly correlated with lymph node metastasis. Moreover, survival analyses revealed that patients who had increased miR-638 levels after chemotherapy showed significantly longer survival time than those who had decreased miR-638 levels. Our findings suggest that serum miR-638 levels are associated with the survival of NSCLC patients and may be considered a potential independent predictor for NSCLC prognosis.
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참고문헌 (27)
참고문헌 신청
[학술지(정기간
Acunzo M / 2012 / miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222 / Oncogene 31 : 634 ~ 642
Ambros V. / 2004 / The functions of animal microRNAs / Nature 431 : 350 ~ 355
Bartel DP / 2004 / MicroRNAs: genomics, biogenesis, mechanism, and function / Cell 116 : 281 ~ 297
Behm-Ansmant I / 2006 / MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay / Cold Spring Harb Symp Quant Biol 71 : 523 ~ 530
Acunzo M / 2012 / miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222 / Oncogene 31 : 634 ~ 642
Ambros V. / 2004 / The functions of animal microRNAs / Nature 431 : 350 ~ 355
Bartel DP / 2004 / MicroRNAs: genomics, biogenesis, mechanism, and function / Cell 116 : 281 ~ 297
Behm-Ansmant I / 2006 / MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay / Cold Spring Harb Symp Quant Biol 71 : 523 ~ 530
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