miR-374 promotes myocardial hypertrophy by negatively regulating vascular endothelial growth factor receptor-1 signaling

LEE JONGSEOB; 송동우; Jei-hyoung Park; 김진옥; Chunghee Cho; 김도한

miR-374 promotes myocardial hypertrophy by negatively regulating vascular endothelial growth factor receptor-1 signaling

Recommendations

Search

Type: Academic journal

Author: LEE JONGSEOB 송동우 Jei-hyoung Park 김진옥 Chunghee Cho 김도한

Journal: KOREAN SOCIETY OF MEDICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY BMB Reports BMB Reports 제50권 제4호 KCI Accredited Journals

Published: 2017.1

Pages: 208 - 213 (6page)

Usage

miR-374 promotes myocardial hypertrophy by negatively regulating vascular endothelial growth factor receptor-1 signaling

Abstract· Keywords

Report Errors

Vascular endothelial growth factor (VEGF) is an essential cytokine that has functions in the formation of new blood vessels and regression of cardiac hypertrophy. VEGF/VEGFreceptor- 1 (VEGFR1) signaling plays a key role in the regression of cardiac hypertrophy, whereas VEGF/VEGFR2 signaling leads to cardiac hypertrophy. In this study, we identified the prohypertrophic role of miR-374 using neonatal rat ventricular myocytes (NRVMs). Our results showed that overexpression of miR-374 activated G protein-coupled receptor-mediated prohypertrophic pathways by the inhibition of VEGFR1-dependent regression pathways. Luciferase assays revealed that miR-374 could directly target the 3’-untranslated regions of VEGFR1 and cGMP-dependent protein kinase-1. Collectively, these findings demonstrated that miR-374 was a novel pro-hypertrophic microRNA functioning to suppress the VEGFR1-mediated regression pathway.

#Cardiac hypertrophy #cGMP-dependent protein kinase-1 #MicroRNA #Neonatal rat ventricular myocytes #Vascular endothelial growth factor signaling

No content found

References (24)

Add References

Cantley LC / 2002 / The phosphoinositide 3-kinase pathway / Science 296 : 1655 ~ 1657

Carmeliet P / 2000 / Molecular basis of angiogenesis. Role of VEGF and VE-cadherin / Ann N Y Acad Sci 902 : 249 ~ 262

Castaldi A / 2014 / MicroRNA- 133 modulates the ?1-adrenergic receptor transduction cascade / Circ Res 115 : 273 ~ 283

Ferrara N / 1999 / Molecular and biological properties of vascular endothelial growth factor / J Mol Med 77 : 527 ~ 543

Frey N / 2003 / Cardiac hypertrophy: the good, the bad, and the ugly / Annu Rev Physiol 65 : 45 ~ 79

Recommendations

It is an article recommended by DBpia according to the article similarity. Check out the related articles!