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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.5
- 수록면
- 244 - 249 (6page)
- DOI
- https://doi.org/10.5483/BMBRep.2023-0150
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초록· 키워드
오류제보하기
Many types of cancer are associated with excessive angiogenesis. Anti-angiogenic treatment is an effective strategy for treating solid cancers. This study aimed to demonstrate the inhibitory effects of (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl)phenol (MMPP) in VEGFA-induced angiogenesis. The results indicated that MMPP effectively suppressed various angiogenicprocesses, such as cell migration, invasion, tube formation, andsprouting of new vessels in human umbilical vein endothelialcells (HUVECs) and mouse aortic ring. The inhibitory mechanismof MMPP on angiogenesis involves targeting VEGFR2. MMPPshowed high binding affinity for the VEGFR2 ATP-binding domain. Additionally, MMPP improved VEGFR2 thermal stabilityand inhibited VEGFR2 kinase activity, suppressing the downstream VEGFR2/AKT/ERK pathway. MMPP attenuated the activation and nuclear translocation of NF-κB, and it downregulated NF-κB target genes such as VEGFA, VEGFR2, MMP2, andMMP9. Furthermore, conditioned medium from MMPP-treatedbreast cancer cells effectively inhibited angiogenesis in endothelial cells. These results suggested that MMPP had great promiseas a novel VEGFR2 inhibitor with potent anti-angiogenic properties for cancer treatment via VEGFR2/AKT/ERK/NF-κB signaling pathway.
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