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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 461 - 466 (6page)
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Epigallocatechin gallate (EGCG) and curcumin are well known to naturally-occurring anticancer agents. The aim of this study was to verify the combined beneficial anticancer effects of curcumin and EGCG on PC3 prostate cancer cells, which are resistant to chemotherapy drugs and apoptosis inducers. EGCG showed weaker inhibitory effect on PC3 cell proliferation than two other prostate cancer cell lines, LNCaP and DU145.
Co-treatment of curcumin improved antiproliferative effect of EGCG on PC3 cells. The protein expressions of p21 were significantly increased by the co-treatment of EGCG and curcumin, whereas it was not changed by the treatment with each individual compound. Moreover, treatments of EGCG and curcumin arrested both S and G2/M phases of PC3 cells. These results suggest that the enhanced inhibitory effect of EGCG on PC3 cell proliferation by curcumin was mediated by the synergic up-regulation of p21-induced growth arrest and followed cell growth arrest
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참고문헌 (24)
참고문헌 신청
Adhami VM / 2003 / Molecular targets for green tea in prostate cancer prevention / J Nutr 133 : 2417 ~ 2424
Ahmad KA / 2007 / Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells / Mol Cancer Ther 6 : 1006 ~ 1012
Ahmad N / 2000 / Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells / Arch Biochem Biophys 37
Banerjee S / 2005 / Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreati
Borska S / 2003 / Induction of apoptosis by EGCG in selected tumour cell lines in vitro / Folia Histochem Cytobiol 41 : 229 ~ 232
Ahmad KA / 2007 / Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells / Mol Cancer Ther 6 : 1006 ~ 1012
Ahmad N / 2000 / Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells / Arch Biochem Biophys 37
Banerjee S / 2005 / Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreati
Borska S / 2003 / Induction of apoptosis by EGCG in selected tumour cell lines in vitro / Folia Histochem Cytobiol 41 : 229 ~ 232
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