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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 297 - 302 (6page)
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Loss of pancreatic -cells by oxidative stress or cytokines is associated with diabetes mellitus (DM). DJ-1 is known to as a multifunctional protein, which plays an important role in cell survival. We prepared cell permeable wild type (WT) and mutant type (M26I) Tat-DJ-1 proteins to investigate the effects of DJ-1 against combined cytokines (IL-1, IFN- and TNF-)-induced RINm5F cell death. Both Tat-DJ-1 proteins were transduced into RINm5F cells. WT Tat-DJ-1 proteins significantly protected against cell death from cytokines by reducing intracellular toxicities. Also, WT Tat-DJ-1 proteins markedly regulated cytokines-induced pro- and anti-apoptosis proteins. However, M26I Tat-DJ-1 protein showed relatively low protective effects, as compared to WT Tat-DJ-1 protein.
Our experiments demonstrated that WT Tat-DJ-1 protein protects against cytokine-induced RINm5F cell death by suppressing intracellular toxicities and regulating apoptosisrelated protein expression. Thus, WT Tat-DJ-1 protein could potentially serve as a therapeutic agent for DM and cytokine related diseases.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Eizirik DL / 2009 / The role of inflammation in insulitis, beta-cell loss in type 1diabetes / Nat Rev Endocrinol 5:219~226
Cnop M / 2007 / Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes / Diabetes Care 30:677~682
Shaw JE / 2010 / Global estimates of the prevalence of diabetes for 2010, 2030 / Diabetes Res Clin Pr 87:4~14
Agrawal NK / 2007 / Cilostazol reduces inflammatory burden, oxidative stress in hypertensive type 2 diabetes mellitus patients / Pharmacol Res 56:118~123
Lundh M / 2013 / Small-molecule inhibition of inflammatory beta cell death / Diabetes Obes Metab 15(Suppl 3):176~184
Cnop M / 2007 / Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes / Diabetes Care 30:677~682
Shaw JE / 2010 / Global estimates of the prevalence of diabetes for 2010, 2030 / Diabetes Res Clin Pr 87:4~14
Agrawal NK / 2007 / Cilostazol reduces inflammatory burden, oxidative stress in hypertensive type 2 diabetes mellitus patients / Pharmacol Res 56:118~123
Lundh M / 2013 / Small-molecule inhibition of inflammatory beta cell death / Diabetes Obes Metab 15(Suppl 3):176~184
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