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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 458 - 463 (6page)
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Cytokines activate inflammatory signals and are major mediatorsin progressive β-cell damage, which leads to type 1 diabetes mellitus.
We recently showed that the cell-permeable Tat-CIAPIN1fusion protein inhibits neuronal cell death induced by oxidativestress. However, how the Tat-CIAPIN1 protein affects cytokine-induced β-cell damage has not been investigated yet.
Thus, we assessed whether the Tat-CIAPIN1 protein can protectRINm5F β-cells against cytokine-induced cytotoxicity. In cytokineexposedRINm5F β-cells, the transduced Tat-CIAPIN1 proteinelevated cell survivals and reduced reactive oxygen species(ROS) and DNA fragmentation levels. The Tat-CIAPIN1 proteinreduced mitogen-activated protein kinases (MAPKs) and NF-κBactivation levels and elevated Bcl-2 protein, whereas Bax andcleaved Caspase-3 proteins were decreased by this fusion protein.
Thus, the protection of RINm5F β-cells by the Tat-CIAPIN1protein against cytokine-induced cytotoxicity can suggest thatthe Tat-CIAPIN1 protein might be used as a therapeutic inhibitoragainst RINm5F β-cell damage.
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참고문헌 (52)
참고문헌 신청
Welters A / 2014 / Metabolism of human diseases:organ physiology and pathophysiology / Springer :163~173
Katsarou A / 2017 / Type 1 diabetes mellitus / Nat Rev Dis Primers 3:17016
Lukic ML / 2014 / New insight into early events in type 1 diabetes : role for islet stem cell exosomes / Diabetes 63:835~837
Patterson CC / 2012 / Trends in childhood type 1 diabetes incidence in Europe during 1989-2008 : evidence of non-uniformity over time in rates of increase / Diabetologia 55:2142~2147
Patterson CC / 2009 / EURODIAB Study Group : incidence trends for childhood type 1 diabetes in Europe during 1989-2003and predicted new cases 2005-20 : a multicentre prospective registration study / Lancet 373:2027~2033
Katsarou A / 2017 / Type 1 diabetes mellitus / Nat Rev Dis Primers 3:17016
Lukic ML / 2014 / New insight into early events in type 1 diabetes : role for islet stem cell exosomes / Diabetes 63:835~837
Patterson CC / 2012 / Trends in childhood type 1 diabetes incidence in Europe during 1989-2008 : evidence of non-uniformity over time in rates of increase / Diabetologia 55:2142~2147
Patterson CC / 2009 / EURODIAB Study Group : incidence trends for childhood type 1 diabetes in Europe during 1989-2003and predicted new cases 2005-20 : a multicentre prospective registration study / Lancet 373:2027~2033
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Hindsiipropane B alleviates HIV-1 Tat-induced inflammatory responses by suppressing HDAC6-NADPH oxidase-ROS axis in astrocytes
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