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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 293 - 296 (4page)
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The immunoregulatory cytokine Interleukin 10 (IL-10) protein is produced by various cells during the course of inflammatory disorders. Mainly, it downregulates pro-inflammatory cytokines, antigen presentation, and helper T cell activation. In this study, we show that the ratio of IL-10-producing cells was significantly increased in lineage negative (i.e., not T, B, or leukocyte cell lineages) cells than in lineage positive cells in lymphoid and peripheral tissues. We further observed that IL-10-producing innate lymphoid cells (ILCs), here called firstly ILC10, were increased in number in oxazolone-induced contact hypersensitivity (CHS) mice. In detail, IL-10-producing lineage negative cells were elevated in the axillary, inguinal lymph node, and ear tissues of CHS mice. Notably, the cells expressed classical ILC marker proteins such as CD45, CD127, and Sca-1. Altogether, our findings suggest for the first time that ILC10s are present in various physiological settings and could be involved in numerous immune responses as regulatory cells.
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참고문헌 (25)
참고문헌 신청
Koyasu S / 2012 / Role of innate lymphocytes in infection, inflammation / Front Immunol 3:101
Spits H / 2012 / Innate lymphoid cells:emerging insights in development, lineage relationships, and function / Annu Rev Immunol 30:647~675
Diefenbach A / 2014 / Development, differentiation, and diversity of innate lymphoid cells / Immunity 41:354~365
Spits H / 2013 / Innate lymphoid cells-a proposal for uniform nomenclature / Nat Rev Immunol 13:145~149
Fuchs A / 2013 / Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12-and IL-15-responsive IFN-γ-producing cells / Immunity 38:769~781
Spits H / 2012 / Innate lymphoid cells:emerging insights in development, lineage relationships, and function / Annu Rev Immunol 30:647~675
Diefenbach A / 2014 / Development, differentiation, and diversity of innate lymphoid cells / Immunity 41:354~365
Spits H / 2013 / Innate lymphoid cells-a proposal for uniform nomenclature / Nat Rev Immunol 13:145~149
Fuchs A / 2013 / Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12-and IL-15-responsive IFN-γ-producing cells / Immunity 38:769~781
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