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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 283 - 288 (6page)
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Foxp3＋ regulatory CD4＋ T (Treg) cells play an essential role in preventing overt immune responses against self and innocuous foreign antigens. Selective expansion of endogenous Treg cells in response to the administration of interleukin (IL)-2/antibody complex, such as the IL-2/JES6-1 complex (IL-2C) in mice, is considered an attractive therapeutic approach to various immune disorders. Here, we investigated the therapeutic potential of IL-2C in allergic airway inflammation models. IL-2C treatment ameliorated Th17-mediated airway inflammation; however, unexpectedly, IL-2C treatment exacerbated Th2-mediated allergic airway inflammation by inducing the selective expansion of Th2 cells and type-2 innate lymphoid cells. We also found that IL-2 signaling is required for the expansion of Th2 cells in lymphoproliferative disease caused by Treg cell depletion. Our data suggest that IL-2C is selectively applicable to the treatment of allergic airway diseases depending on the characteristics of airway inflammation.
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참고문헌 (28)
참고문헌 신청
Josefowicz SZ / 2012 / Regulatory T cells : mechanisms of differentiation and function / Annu Rev Immunol 30:531~564
Noval Rivas M / 2016 / Regulatory T cells in allergic diseases / J Allergy Clin Immunol 138:639~652
Thorburn AN / 2010 / Harnessing regulatory T cells to suppress asthma : from potential to therapy / Am J Respir Cell Mol Biol 43:511~519
Mamessier E / 2008 / T-cell activation during exacerbations : a longitudinal study in refractory asthma / Allergy 63:1202~1210
Kearley J / 2005 / Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4＋CD25＋ regulatory T cells is interleukin 10 dependent / J Exp Med 202:1539~1547
Noval Rivas M / 2016 / Regulatory T cells in allergic diseases / J Allergy Clin Immunol 138:639~652
Thorburn AN / 2010 / Harnessing regulatory T cells to suppress asthma : from potential to therapy / Am J Respir Cell Mol Biol 43:511~519
Mamessier E / 2008 / T-cell activation during exacerbations : a longitudinal study in refractory asthma / Allergy 63:1202~1210
Kearley J / 2005 / Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4＋CD25＋ regulatory T cells is interleukin 10 dependent / J Exp Med 202:1539~1547
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