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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 263 - 269 (7page)
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초록· 키워드
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The intestine represents the largest and most elaborate immune system organ, in which dynamic and reciprocal interplay among numerous immune and epithelial cells, commensal microbiota, and external antigens contributes to establishing both homeostatic and pathologic conditions. The mechanisms that sustain gut homeostasis are pivotal in maintaining gut health in the harsh environment of the gut lumen.
Intestinal epithelial cells are critical players in creating the mucosal platform for interplay between host immune cells and luminal stress inducers. Thus, knowledge of the epithelial interface between immune cells and the luminal environment is a prerequisite for a better understanding of gut homeostasis and pathophysiologies such as inflammation. In this review, we explore the importance of the epithelium in limiting or promoting gut inflammation (e.g., inflammatory bowel disease). We also introduce recent findings on how small RNAs such as microRNAs orchestrate pathophysiologic gene regulation.
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참고문헌 (67)
참고문헌 신청
Kaser A / 2010 / Inflammatory bowel disease / Annu Rev Immunol 28:573~621
Artis D / 2008 / Epithelial-cell recognition of commensal bacteria, maintenance of immune homeostasis in the gut / Nat Rev Immunol 8:411~420
Hooper LV / 2010 / Immune adaptations that maintain homeostasis with the intestinal microbiota / Nat Rev Immunol 10:159~169
Creamer B / 1961 / The turnover, shedding of epithelial cells. I. The turnover in the gastro-intestinal tract / Gut 2:110~118
Barker N / 2007 / Identification of stem cells in small intestine, colon by marker gene Lgr5 / Nature 449:1003~1007
Artis D / 2008 / Epithelial-cell recognition of commensal bacteria, maintenance of immune homeostasis in the gut / Nat Rev Immunol 8:411~420
Hooper LV / 2010 / Immune adaptations that maintain homeostasis with the intestinal microbiota / Nat Rev Immunol 10:159~169
Creamer B / 1961 / The turnover, shedding of epithelial cells. I. The turnover in the gastro-intestinal tract / Gut 2:110~118
Barker N / 2007 / Identification of stem cells in small intestine, colon by marker gene Lgr5 / Nature 449:1003~1007
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