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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 8 (8page)
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The intestine is a unique organ inhabited by a tremendous number of microorganisms. Intestinal epithelial cells greatly contribute to the maintenance of the symbiotic relationship between gut microbiota and the host by constructing mucosal barriers, secreting various immunological mediators and delivering bacterial antigens. Mucosal barriers, including physical barriers and chemical barriers, spatially segregate gut microbiota and the host immune system to avoid unnecessary immune responses to gut microbes, leading to the intestinal inflammation. In addition, various immunological mediators, including cytokines and chemokines, secreted from intestinal epithelial cells stimulated by gut microbiota modulate host immune responses, maintaining a well-balanced relationship between gut microbes and the host immune system. Therefore, impairment of the innate immune functions of intestinal epithelial cells is associated with intestinal inflammation.
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참고문헌 (25)
참고문헌 신청
Atarashi K / 2008 / ATP drives lamina propria T(H)17 cell differentiation / Nature 455 : 808 ~ 812
Ayabe T / 2000 / Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria / Nat Immunol 1 : 113 ~ 118
Brogden KA / 2005 / Antimicrobial peptides : pore formers or metabolic inhibitors in bacteria? / Nat Rev Microbiol 3 : 238 ~ 250
Capaldo CT / 2012 / IFN-gamma and TNF-alpha-induced GBP-1 inhibits epithelial cell proliferation through suppression of beta-catenin/TCF signaling / Mucosal Immunol 5 : 681
Cash HL / 2006 / Symbiotic bacteria direct expression of an intestinal bactericidal lectin / Science 313 : 1126 ~ 1130
Ayabe T / 2000 / Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria / Nat Immunol 1 : 113 ~ 118
Brogden KA / 2005 / Antimicrobial peptides : pore formers or metabolic inhibitors in bacteria? / Nat Rev Microbiol 3 : 238 ~ 250
Capaldo CT / 2012 / IFN-gamma and TNF-alpha-induced GBP-1 inhibits epithelial cell proliferation through suppression of beta-catenin/TCF signaling / Mucosal Immunol 5 : 681
Cash HL / 2006 / Symbiotic bacteria direct expression of an intestinal bactericidal lectin / Science 313 : 1126 ~ 1130
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