지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 42 - 50 (9page)
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초록· 키워드
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Background: The neutrophil-lymphocyte ratio (NLR) is often used as an inflammatory marker in chronic diseases such as cancer or cardiovascular diseases. However, there are few studies about the association between the NLR and diabetes mellitus (DM) or impaired fasting glucose (IFG) patients in Korea. This study investigated the associa-tion between the fasting plasma glucose (FPG) level and NLR in Koreans.Methods: This cross-sectional retrospective study included 3,219 healthy subjects who visited Konyang University Hospital in South Korea for regular health examinations. Participants with a history of insulin administration, anti-diabetic drugs, anti-inflammatory drugs, or underlying diseases related to inflammation were excluded.Results: All statistical evaluation was performed by dividing participants into males and females. Based on FPG levels, the subjects were classified into three groups, with normal fasting glucose (n=1,969), IFG (n=1,138), and DM (n=122). The NLR had no significant mean differences among these groups for both sexes. Multiple linear regres-sion analysis between FPG level and NLR showed an independent and significantly negative association (b±standard error, -0.67±0.24; P=0.006) in normal subjects after adjustment. Log(serum C-reactive protein [S-CRP]) showed an independently and significantly positive association with FPG in male IFG/DM patients. Total leukocyte (white blood cell [WBC]) showed an independently and significantly positive association with FPG in female IFG/DM patients.Conclusion: In normal subjects, NLR shows an independently and significantly negative association with FPG. In IFG/DM patients, NLR was not significantly related to FPG. WBC count in female patients and S-CRP level in male patients were significantly positively associated with FPG only in IFG/DM.
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참고문헌 (30)
참고문헌 신청
Korean Diabetes Association / 2013 / Diabetes fact sheet in Korea 2013 / Korean Diabetes Association
McKeigue PM / 1991 / Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians / Lancet 337:382~386
Shoelson SE / 2006 / Inflammation and insulin resistance / J Clin Invest 116:1793~1801
Bastard JP / 2006 / Recent advances in the relationship between obesity, inflammation, and insulin resistance / Eur Cytokine Netw 17:4~12
Xu H / 2003 / Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance / J Clin Invest 112:1821~1830
McKeigue PM / 1991 / Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians / Lancet 337:382~386
Shoelson SE / 2006 / Inflammation and insulin resistance / J Clin Invest 116:1793~1801
Bastard JP / 2006 / Recent advances in the relationship between obesity, inflammation, and insulin resistance / Eur Cytokine Netw 17:4~12
Xu H / 2003 / Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance / J Clin Invest 112:1821~1830
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