지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 377 - 381 (5page)
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초록· 키워드
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Purpose: To investigate the possible associations of neutrophil-to-lymphocyte ratio (NLR) and high sensitivityC-reactive protein (hs-CRP) level with age-related macular degeneration (ARMD).
Methods: Patients were divided to three groups of 40 patients with non-neovascular ARMD (group 1), 40patients with neovascular ARMD (group 2), and 40 healthy control subjects (group 3). The neutrophil andlymphocyte counts were evaluated using an ABX Pentra DF120/USA biochemical analyzer, and hs-CRP levelswere measured using a Beckman Coulter Immage 800. The NLR was measured by dividing neutrophil countby lymphocyte count.
Results: The patients in group 2 were older and more often diabetic than the patients in groups 1 and 3 (p < 0.001and p < 0.001, respectively). The NLR level was 1.65 ± 0.71 in group 1, 1.98 ± 0.84 in group 2, and 1.46 ± 0.44in group 3. The hs-CRP value was 1.98 ± 0.251 mg/L in group 1, 3.242 ± 0.211 mg/L in group 2, and 1.145 ±0.193 mg/L in group 3. Both NLR and hs-CRP values were significantly higher in group 2 compared to group3 (p = 0.002 and p = 0.002, respectively). In multivariate analysis, NLR remained an independent predictor ofneovascular ARMD (odds ratio, 3.882; 95% confidence interval, 1.574 to 9.576; p = 0.003) together with age (p< 0.001), diabetes mellitus (p = 0.041), and hs-CRP (p = 0.018).
Conclusions: Our study suggests that increased NLR value is independently associated with neovascularARMD.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Subramani S / 2010 / Serum uric acid levels and its association with age-related macular degeneration (ARMD) / Med J Malaysia 65:36~40
Coral K / 2006 / Plasma homocysteine and total thiol content in patients with exudative age-related macular degeneration / Eye (Lond) 20:203~207
Rodrigues EB / 2007 / Inflammation in dry age-related macular degeneration / Ophthalmologica 221:143~152
Anderson DH / 2002 / A role for local inflammation in the formation of drusen in the aging eye / Am J Ophthalmol 134:411~431
Boekhoorn SS / 2007 / C-reactive protein level and risk of aging macula disorder: the Rotterdam Study / Arch Ophthalmol 125:1396~1401
Coral K / 2006 / Plasma homocysteine and total thiol content in patients with exudative age-related macular degeneration / Eye (Lond) 20:203~207
Rodrigues EB / 2007 / Inflammation in dry age-related macular degeneration / Ophthalmologica 221:143~152
Anderson DH / 2002 / A role for local inflammation in the formation of drusen in the aging eye / Am J Ophthalmol 134:411~431
Boekhoorn SS / 2007 / C-reactive protein level and risk of aging macula disorder: the Rotterdam Study / Arch Ophthalmol 125:1396~1401
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