지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 238 - 251 (14page)
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초록· 키워드
오류제보하기
Background Endogenous endophthalmitis (EE) is a fulminant ocular disease. This study was conducted to explore frequent pathogens and significant prognostic factors associated with poor ocular outcomes. Materials and Methods A retrospective analysis was performed in a tertiary hospital in Korea. Thirty-nine patients, treated between January 2000 and June 2017, were eligible for the analysis. Ocular outcomes were classified as follows: 1) no light perception (NLP), 2) light perception (LP), 3) hand motion (HM), 4) counting fingers (CF), and 5) 20/200 or better. Logistic regression and decision tree analyses were used to identify risk factors that were associated with poor outcomes. Results Pathogens were identified in 23 (58.9%) samples from blood, liver aspirate, and/or vitreous humor. Klebsiella pneumoniae was the most frequent organism (12/39, 30.8%), followed by Candida species (3/39, 8.3%). The most common combined infection was liver abscess (16/39, 41.0%). Acute pyelonephritis occurred in 30.8% of cases (12/39). Final ocular outcomes were as follows: 35.9% (14/39) NLP, 15.4% (6/39) LP, 15.4% (6/39) HM, 7.7% (3/39) CF, and 25.6% (10/39) 20/200 or better. K. pneumoniae was a poor prognostic factor in univariate (odds ratio [OR], 13.3; 95% confidence interval [CI], 2.1-130.9) and multivariate (OR, 17.5; 95% CI, 2.1-398.8) regression analyses (NLP and LP vs. HM, CF, and 20/200 or better). Other factors did not reach statistical difference. Decision tree analysis identified K. pneumoniae as a node that divided ocular outcomes (P = 0.017). Conclusions In conclusion, K. pneumoniae is the most frequent causative pathogen of EE. Considering the poor prognosis and rapid progression of K. pneumoniae EE, physicians should test for K. pneumoniae EE in patients who experience acute systemic infections with ocular signs and symptoms.
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참고문헌 (34)
참고문헌 신청
Chee SP / 2001 / Endogenous endophthalmitis / Curr Opin Ophthalmol 12:464~470
Jackson TL / 2003 / Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases / Surv Ophthalmol 48:403~423
Ang M / 2011 / Prognostic factors and outcomes in endogenous Klebsiella pneumoniae endophthalmitis / Am J Ophthalmol 151:338~344
Connell PP / 2011 / Endogenous endophthalmitis: 10-year experience at a tertiary referral centre / Eye (Lond) 25:66~72
Jackson TL / 2014 / Systematic review of 342 cases of endogenous bacterial endophthalmitis / Surv Ophthalmol 59:627~635
Jackson TL / 2003 / Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases / Surv Ophthalmol 48:403~423
Ang M / 2011 / Prognostic factors and outcomes in endogenous Klebsiella pneumoniae endophthalmitis / Am J Ophthalmol 151:338~344
Connell PP / 2011 / Endogenous endophthalmitis: 10-year experience at a tertiary referral centre / Eye (Lond) 25:66~72
Jackson TL / 2014 / Systematic review of 342 cases of endogenous bacterial endophthalmitis / Surv Ophthalmol 59:627~635
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