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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 59 - 64 (6page)
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This study was designed to investigate the changes in the
properties of the neuronal setm cells or progenitor cells
associated with age-related decline in neurogenesis of the
hippocampal dentate gyrus (DG). Active whole cells cycle
marker Ki67 (a marker of whole cell cycle)-positive and S
phase marker bromodeoxyuridine (BrdU)-positive. Neural
stem cells gradually were reduced in the hippocampal
subgranular zone (SGZ) in an age-dependant manner after
birth (from P1 month to P1 year). The ratio of BrdUpositive
cells/Ki67-positive cells was gradually enhanced in
an age-dependent manner. The ratio of Ki67-positive cells/
accu-mulating BrdU-positive cells at 3 hrs after BrdU
injection was injected once a day for consecutive 5 days
gradually decreased during ageing. TUNEL- and caspase 3
(apoptotic terminal caspase)-positive cells gradually
decreased in the dentate SGZ during ageing and immunohistochemical
findings of glial fibrillary acid protein
(GFAP) were not changed during ageing. NeuN, a marker of
mature neural cells, and BrdU-double positive cells
gradually decreased in an age-dependent manner but
differentiating ratio and survival rate of cells were not
changed at 4 wks after BrdU injection once a day for
consecutive 5 days. The number of BrdU-positive cells
migrated from the hippocampal SGZ into granular layer
and its migration speed was gradually declined during
ageing. These results suggest that the adult neurogenesis in
the mouse hippocampal DG gradually decrease through
reducing proliferation of neural stem cells accompanying with cells cycle change and reduced cells migration rather
than changes of differentiation.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Cameron H. A / 1994 / Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus / Neuroscience 61 : 203 ~ 209
Campisi J. / 2005 / Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors / Cell 120 : 513 ~ 522
Eriksson P. S. / 1998 / Neurogenesis in the adult human hippocampus / Nature Medicine 4 : 1313 ~ 1317
Gage F. H. / 1995 / Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain / Proceedings of the National Academy of Sciences of the United
Georg K. H. / 1996 / Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation / Journal of Neuroscience 76 : 2027 ~ 2033
Campisi J. / 2005 / Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors / Cell 120 : 513 ~ 522
Eriksson P. S. / 1998 / Neurogenesis in the adult human hippocampus / Nature Medicine 4 : 1313 ~ 1317
Gage F. H. / 1995 / Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain / Proceedings of the National Academy of Sciences of the United
Georg K. H. / 1996 / Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation / Journal of Neuroscience 76 : 2027 ~ 2033
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